Understanding the Role of Rho GTPase Activating Protein and Bone Marrow Kinase X: A Novel Target in Gastric Cancer Treatment.

Q2 Medicine

Asian Pacific Journal of Cancer Prevention Pub Date : 2025-03-01 DOI:10.31557/APJCP.2025.26.3.725

Zakari Shaibu, Zhihong Chen, Fumeng Yang, Xiaofeng Xu, Yong Ji, Wei Zhu

{"title":"Understanding the Role of Rho GTPase Activating Protein and Bone Marrow Kinase X: A Novel Target in Gastric Cancer Treatment.","authors":"Zakari Shaibu, Zhihong Chen, Fumeng Yang, Xiaofeng Xu, Yong Ji, Wei Zhu","doi":"10.31557/APJCP.2025.26.3.725","DOIUrl":null,"url":null,"abstract":"Objective: To review the role of Rho GTPase Activating Protein (ARHGAP) and Bone Marrow Kinase X (BMX) in the progression and development of gastric cancer (GC), and to highlight their potential as therapeutic targets.Method: A comprehensive literature review was conducted to assess current evidence regarding the involvement of ARHGAP and BMX in GC, focusing on their expression levels, association with prognosis, and impact on tumor behavior.Results: Current research indicates that both ARHGAP and BMX are up-regulated in GC tissues, correlating with poor prognosis and aggressive tumor characteristics. These findings suggest that they play significant roles in the mechanisms underlying GC progression.Conclusion: The evidence supports the critical involvement of ARHGAP and BMX in GC, suggesting their potential as therapeutic targets. Further research is essential to clarify the mechanisms by which these proteins influence gastric cancer progression and to evaluate their viability as targets for new therapeutic strategies.","PeriodicalId":55451,"journal":{"name":"Asian Pacific Journal of Cancer Prevention","volume":"26 3","pages":"725-733"},"PeriodicalIF":0.0000,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Asian Pacific Journal of Cancer Prevention","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.31557/APJCP.2025.26.3.725","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"Medicine","Score":null,"Total":0}

引用次数: 0

Abstract

Objective: To review the role of Rho GTPase Activating Protein (ARHGAP) and Bone Marrow Kinase X (BMX) in the progression and development of gastric cancer (GC), and to highlight their potential as therapeutic targets.

Method: A comprehensive literature review was conducted to assess current evidence regarding the involvement of ARHGAP and BMX in GC, focusing on their expression levels, association with prognosis, and impact on tumor behavior.

Results: Current research indicates that both ARHGAP and BMX are up-regulated in GC tissues, correlating with poor prognosis and aggressive tumor characteristics. These findings suggest that they play significant roles in the mechanisms underlying GC progression.

Conclusion: The evidence supports the critical involvement of ARHGAP and BMX in GC, suggesting their potential as therapeutic targets. Further research is essential to clarify the mechanisms by which these proteins influence gastric cancer progression and to evaluate their viability as targets for new therapeutic strategies.

查看原文本刊更多论文

求助全文

约1分钟内获得全文求助全文

来源期刊

Asian Pacific Journal of Cancer Prevention 医学-肿瘤学

CiteScore

2.80

自引率

0.00%

发文量

779

审稿时长

3 months

期刊介绍： Cancer is a very complex disease. While many aspects of carcinoge-nesis and oncogenesis are known, cancer control and prevention at the community level is however still in its infancy. Much more work needs to be done and many more steps need to be taken before effective strategies are developed. The multidisciplinary approaches and efforts to understand and control cancer in an effective and efficient manner, require highly trained scientists in all branches of the cancer sciences, from cellular and molecular aspects to patient care and palliation. The Asia Pacific Organization for Cancer Prevention (APOCP) and its official publication, the Asia Pacific Journal of Cancer Prevention (APJCP), have served the community of cancer scientists very well and intends to continue to serve in this capacity to the best of its abilities. One of the objectives of the APOCP is to provide all relevant and current scientific information on the whole spectrum of cancer sciences. They aim to do this by providing a forum for communication and propagation of original and innovative research findings that have relevance to understanding the etiology, progression, treatment, and survival of patients, through their journal. The APJCP with its distinguished, diverse, and Asia-wide team of editors, reviewers, and readers, ensure the highest standards of research communication within the cancer sciences community across Asia as well as globally. The APJCP publishes original research results under the following categories: -Epidemiology, detection and screening. -Cellular research and bio-markers. -Identification of bio-targets and agents with novel mechanisms of action. -Optimal clinical use of existing anti-cancer agents, including combination therapies. -Radiation and surgery. -Palliative care. -Patient adherence, quality of life, satisfaction. -Health economic evaluations.