Raghad N Shihab, Atheer Abd Elqader Zain Elabdeen, Samar Ahmed Jabbar
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引用次数: 0
Abstract
Background: Thyroid cancer is a prevalent endocrine malignancy, and identifying reliable molecular markers is crucial. This study evaluates the diagnostic potential of the thyroid-stimulating hormone receptor (TSHR) and vascular adhesion protein-1 (VAP-1).
Materials and methods: A total of 90 patients with thyroid disorders including malignant tumors, benign tumors, and hyperthyroidism were recruited from the Al-Amal National Hospital for Cancer Management in Baghdad (March-June 2022). Twenty-five age-matched healthy individuals served as controls. Serum levels of T3, T4, TSH, and thyroglobulin (Tg) were measured along with TSHR and VAP-1 using commercial sandwich ELISA kits.
Results: Patients with thyroid cancer exhibited significantly elevated levels of T3 and T4, as well as markedly increased Tg concentrations, compared to controls. In contrast, TSH levels were significantly reduced (P < 0.001). Notably, VAP-1 levels were significantly lower in thyroid cancer patients when compared with both healthy controls and patients with other thyroid disorders (P < 0.001), while TSHR levels did not differ significantly among the groups.
Conclusion: The distinct hormonal profile observed characterized by increased T3, T4, and Tg, alongside a significant reduction in VAP-1 suggests that low serum VAP-1 may serve as a useful diagnostic marker for thyroid cancer. These findings underscore the complex interplay between thyroid function and tumor biology and warrant further investigation into the molecular mechanisms underlying these alterations.
期刊介绍：
Cancer is a very complex disease. While many aspects of carcinoge-nesis and oncogenesis are known, cancer control and prevention at the community level is however still in its infancy. Much more work needs to be done and many more steps need to be taken before effective strategies are developed. The multidisciplinary approaches and efforts to understand and control cancer in an effective and efficient manner, require highly trained scientists in all branches of the cancer sciences, from cellular and molecular aspects to patient care and palliation.
The Asia Pacific Organization for Cancer Prevention (APOCP) and its official publication, the Asia Pacific Journal of Cancer Prevention (APJCP), have served the community of cancer scientists very well and intends to continue to serve in this capacity to the best of its abilities. One of the objectives of the APOCP is to provide all relevant and current scientific information on the whole spectrum of cancer sciences. They aim to do this by providing a forum for communication and propagation of original and innovative research findings that have relevance to understanding the etiology, progression, treatment, and survival of patients, through their journal. The APJCP with its distinguished, diverse, and Asia-wide team of editors, reviewers, and readers, ensure the highest standards of research communication within the cancer sciences community across Asia as well as globally.
The APJCP publishes original research results under the following categories:
-Epidemiology, detection and screening.
-Cellular research and bio-markers.
-Identification of bio-targets and agents with novel mechanisms of action.
-Optimal clinical use of existing anti-cancer agents, including combination therapies.
-Radiation and surgery.
-Palliative care.
-Patient adherence, quality of life, satisfaction.
-Health economic evaluations.
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