Fcodes update: a kinship encoding framework with F-Tree GUI & LLM inference.

IF 1.5 Q3 MATHEMATICAL & COMPUTATIONAL BIOLOGY
Daniel Pérez-Rodríguez, Roberto C Agís-Balboa, Hugo López-Fernández
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Abstract

Family structures play a crucial role in personal development, social dynamics, and mental health. Traditional systems for encoding genealogical data, such as Ahnentafel and the Register System, offer methods to document lineage but face limitations, particularly in accommodating horizontal relationships or handling changes in family datasets. Modern computational systems like LINKAGE and PED, while powerful for genetic analysis, lack human readability and are challenging to apply in fields where unstructured, narrative data is common, such as sociology or psychiatry. This paper aims to bridge this gap by enhancing Fcodes, a flexible and intuitive algorithm for encoding kinship relationships that is suited for both manual and computational use. Building on our previous work, we present improvements to the Fcodes core algorithm and command-line interface (CLI), as well as the development of F-Tree, a new graphical user interface (GUI) to streamline the encoding process. Additionally, we introduce a method for estimating the coefficient of inbreeding using Fcodes and explore the application of artificial intelligence, namely large language models (LLMs), to automatically infer family relationships from narrative text. These advancements highlight the potential of Fcodes in a wide range of research contexts, from social studies to genetics and mental health research.

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来源期刊
Journal of Integrative Bioinformatics
Journal of Integrative Bioinformatics Medicine-Medicine (all)
CiteScore
3.10
自引率
5.30%
发文量
27
审稿时长
12 weeks
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