Association between admission serum calcium levels and in‑hospital mortality in acute myocardial infarction patients with cardiovascular-kidney-metabolic syndrome.
Jing Xu, Shuai Yu, Jian Huang, Li Geng, Yumiao Wei, Xin Li, Xin Gong
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引用次数: 0
Abstract
Purpose: Acute myocardial infarction (AMI) with cardiovascular-kidney-metabolic (CKM) condition is linked to a high in-hospital mortality. Some previous studies reported that calcium may be related with in-hospital mortality among patients with AMI. However, there is no report about the association between serum calcium and AMI patients with CKM syndrome. Therefore, this study investigated the association between admission serum calcium levels and in-hospital mortality in a cohort of AMI patients with CKM syndrome.
Methods: This retrospective cohort study enrolled 2537 admitted patients with AMI including 270 patients with CKM. All the data were extracted from electronic medical records from May 2019 to April 2024. According to the reference range of serum calcium, all the 270 patients were divided into two groups, low calcium group (0-2.10 mmol/L) and non-low calcium group (from 2.11 mmol/L). The primary endpoint was in-hospital mortality.
Results: The in-hospital mortality rate was significantly higher in the low calcium cohort (16.8%, n = 19) compared to the non-low calcium group (8.3%, n = 13). After adjusting for age, gender, hypertension, atrial fibrillation, stroke and smoke, patients in the low calcium group demonstrated significantly higher in-hospital mortality compared to the non-low calcium group (OR = 2.409, 95% CI: 1.105-5.249, p < 0.05). In subgroup analyses, the multivariable logistic regression models indicated that serum calcium was an independent predictor for in-hospital mortality in females (OR = 7.453; 95% CI = 1.751-31.730; p < 0.05) and elderly patients (OR = 3.122; 95% CI = 1.167-8.348; p < 0.05) after adjustments for hypertension, atrial fibrillation, stroke and smoke. Restricted cubic splines (RCS) regression analysis showed a dose-response relationship between serum calcium and in-hospital mortality (nonlinear P value = 0.067).
Conclusions: Admission hypocalcemia is an independent risk factor of in-hospital mortality in AMI patients with CKM syndrome, especially in elderly individuals (aged ≥76 years) and females.
期刊介绍：
Well-established as a major journal in today’s rapidly advancing experimental and clinical research areas, Endocrine publishes original articles devoted to basic (including molecular, cellular and physiological studies), translational and clinical research in all the different fields of endocrinology and metabolism. Articles will be accepted based on peer-reviews, priority, and editorial decision. Invited reviews, mini-reviews and viewpoints on relevant pathophysiological and clinical topics, as well as Editorials on articles appearing in the Journal, are published. Unsolicited Editorials will be evaluated by the editorial team. Outcomes of scientific meetings, as well as guidelines and position statements, may be submitted. The Journal also considers special feature articles in the field of endocrine genetics and epigenetics, as well as articles devoted to novel methods and techniques in endocrinology.
Endocrine covers controversial, clinical endocrine issues. Meta-analyses on endocrine and metabolic topics are also accepted. Descriptions of single clinical cases and/or small patients studies are not published unless of exceptional interest. However, reports of novel imaging studies and endocrine side effects in single patients may be considered. Research letters and letters to the editor related or unrelated to recently published articles can be submitted.
Endocrine covers leading topics in endocrinology such as neuroendocrinology, pituitary and hypothalamic peptides, thyroid physiological and clinical aspects, bone and mineral metabolism and osteoporosis, obesity, lipid and energy metabolism and food intake control, insulin, Type 1 and Type 2 diabetes, hormones of male and female reproduction, adrenal diseases pediatric and geriatric endocrinology, endocrine hypertension and endocrine oncology.
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