Efficacy of Aqueous Extract of Talinum Triangulare on the Microanatomy of the Hippocampus and Short-Term Memory of Scopolamine Hydrobromide-Induced Alzheimer's Type Cognitive Dysfunction Rats.

Q4 Medicine
Eru Mba, Gabriel U Udo-Affah, I F Bassey, K C Uruakpa, S O Paulinus, M E Oku, N M Umoh, S E Anani, A O Agiri
{"title":"Efficacy of Aqueous Extract of Talinum Triangulare on the Microanatomy of the Hippocampus and Short-Term Memory of Scopolamine Hydrobromide-Induced Alzheimer's Type Cognitive Dysfunction Rats.","authors":"Eru Mba, Gabriel U Udo-Affah, I F Bassey, K C Uruakpa, S O Paulinus, M E Oku, N M Umoh, S E Anani, A O Agiri","doi":"10.54548/njps.v39i1.13","DOIUrl":null,"url":null,"abstract":"<p><p>The study aimed at elucidating the potency of aqueous extract of Talinum triangulare on the hippocampal neurons, astrocytes as well as assessing short term memory of scopolamine-induced Alzheimer's type rats. Fifty-four Wistar rats (180-200g) were used for the study; thirty experimental rats were randomly grouped into five, each containing six rats designated A, B, C, D and E while twenty-four rats were used to establish 50% lethal dose (LD50). Alzheimer's type cognitive dysfunction was intraperitoneally (ip) induced with scopolamine hydrobromide (1mg/kg, ip) for seven days in groups B-E prior to the oral administration of the aqueous extract (875 and 1750mg/kg) and donepezil (1mg/kg), followed by the novel object recognition test, histological and GFAP staining processes. Results revealed atrophied pyramidal cells, hyperchromatic, numerous glial cells with pale cytoplasmic inclusions and astrogliosis in groups B, C, and E while group D showed ameliorative potentials compared to group A. Also, short term memory was significantly higher in group D compared to groups B, C and E. In conclusion, aqueous extract of Talinium triangulare leaves reduced the potentials of scopolamine hydrobromide by restoring abnormal neurons, hence, enhancing cognitive memory in the rats used in the present study.</p>","PeriodicalId":35043,"journal":{"name":"Nigerian Journal of Physiological Sciences","volume":"39 1","pages":"101-109"},"PeriodicalIF":0.0000,"publicationDate":"2025-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nigerian Journal of Physiological Sciences","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.54548/njps.v39i1.13","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 0

Abstract

The study aimed at elucidating the potency of aqueous extract of Talinum triangulare on the hippocampal neurons, astrocytes as well as assessing short term memory of scopolamine-induced Alzheimer's type rats. Fifty-four Wistar rats (180-200g) were used for the study; thirty experimental rats were randomly grouped into five, each containing six rats designated A, B, C, D and E while twenty-four rats were used to establish 50% lethal dose (LD50). Alzheimer's type cognitive dysfunction was intraperitoneally (ip) induced with scopolamine hydrobromide (1mg/kg, ip) for seven days in groups B-E prior to the oral administration of the aqueous extract (875 and 1750mg/kg) and donepezil (1mg/kg), followed by the novel object recognition test, histological and GFAP staining processes. Results revealed atrophied pyramidal cells, hyperchromatic, numerous glial cells with pale cytoplasmic inclusions and astrogliosis in groups B, C, and E while group D showed ameliorative potentials compared to group A. Also, short term memory was significantly higher in group D compared to groups B, C and E. In conclusion, aqueous extract of Talinium triangulare leaves reduced the potentials of scopolamine hydrobromide by restoring abnormal neurons, hence, enhancing cognitive memory in the rats used in the present study.

三角taltalum水提物对氢溴酸东莨菪碱诱导的阿尔茨海默型认知功能障碍大鼠海马微观解剖及短期记忆的影响。
本研究旨在阐明三角Talinum水提物对东莨菪碱诱导的阿尔茨海默病大鼠海马神经元、星形胶质细胞的作用,并评估其短期记忆。实验用Wistar大鼠54只(180 ~ 200g);实验大鼠30只,随机分为5组,每组6只,按A、B、C、D、E编号,取24只大鼠建立50%致死剂量(LD50)。B-E组在口服水提取物(875和1750mg/kg)和多奈哌齐(1mg/kg)之前,用氢溴酸东莨菪碱(1mg/kg, ip)腹腔诱导阿尔茨海默氏型认知功能障碍7天,然后进行新的物体识别测试、组织学和GFAP染色。结果显示,B、C、E组大鼠锥体细胞萎缩,色素深染,胶质细胞数量多,胞浆包体苍白,星形胶质细胞增多,D组大鼠短期记忆能力显著高于B、C、E组。综上所述,三角Talinium叶水提物通过恢复异常神经元,降低氢溴酸东莨菪碱电位。增强本研究所用大鼠的认知记忆。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
Nigerian Journal of Physiological Sciences
Nigerian Journal of Physiological Sciences Medicine-Physiology (medical)
CiteScore
0.80
自引率
0.00%
发文量
23
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信