Advances in synthesizing plant-derived isoflavones and their precursors with multiple pharmacological activities using engineered yeasts.

IF 4.3 2区生物学 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Microbial Cell Factories Pub Date : 2025-03-29 DOI:10.1186/s12934-025-02692-2

Wenhui Niu, Jingxian Zhang, Lingbo Qu, Xiao-Jun Ji, Yongjun Wei

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引用次数: 0

Abstract

Isoflavones such as daidzein and genistein are naturally occurring compounds found in plants such as legumes. They have diverse pharmacological activities, making them valuable in the food, pharmaceutical, and cosmetic industries. Currently, isoflavones are mainly obtained through the extraction of plant biomass. Chemical synthesis is challenging for most isoflavones due to the complexity of their structures. The limited supply of isoflavones cannot meet the market demands. Advances in synthetic biology have provided a sustainable and efficient solution for the production of isoflavones, with yeasts often serving as the microbial chassis for biosynthesis. This review summarizes the pharmacological properties of specific isoflavones, their biosynthetic pathways, and the technical strategies used in engineered yeasts for isoflavone production. In addition, the development of synthetic biology and state-of-the-art biotechnological strategies for the environmentally friendly production of bioactive isoflavones is discussed.

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利用工程酵母合成具有多种药理活性的植物源异黄酮及其前体的研究进展。

大豆黄素和染料木素等异黄酮是在豆类等植物中发现的天然化合物。它们具有多种药理活性，使它们在食品、制药和化妆品工业中很有价值。目前，异黄酮主要是从植物生物量中提取。由于异黄酮结构的复杂性，化学合成对大多数异黄酮具有挑战性。异黄酮供应有限，不能满足市场需求。合成生物学的进步为异黄酮的生产提供了可持续和高效的解决方案，酵母通常作为生物合成的微生物底盘。本文综述了异黄酮的药理特性、生物合成途径以及工程酵母生产异黄酮的技术策略。此外，还讨论了合成生物学的发展和环境友好型生产生物活性异黄酮的最新生物技术战略。

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来源期刊

Microbial Cell Factories 工程技术-生物工程与应用微生物

CiteScore

9.30

自引率

4.70%

发文量

235

审稿时长

2.3 months

期刊介绍： Microbial Cell Factories is an open access peer-reviewed journal that covers any topic related to the development, use and investigation of microbial cells as producers of recombinant proteins and natural products, or as catalyzers of biological transformations of industrial interest. Microbial Cell Factories is the world leading, primary research journal fully focusing on Applied Microbiology. The journal is divided into the following editorial sections: -Metabolic engineering -Synthetic biology -Whole-cell biocatalysis -Microbial regulations -Recombinant protein production/bioprocessing -Production of natural compounds -Systems biology of cell factories -Microbial production processes -Cell-free systems