Chromogenic and Fluorogenic Schiff Bases for Toxic Analyte Detection: A Review on ESIPT-Based Recognition.

IF 2.6 4区化学 Q2 BIOCHEMICAL RESEARCH METHODS

Journal of Fluorescence Pub Date : 2025-03-29 DOI:10.1007/s10895-025-04271-5

Duraisamy Udhayakumari

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引用次数: 0

Abstract

Schiff base probes have emerged as highly effective chromogenic and fluorogenic sensors for the selective detection of toxic cations and anions. Among various sensing mechanisms, Excited-State Intramolecular Proton Transfer (ESIPT) has gained significant attention due to its rapid response, high sensitivity, and tunable optical properties. This review highlights recent advancements in ESIPT-based Schiff base probes for toxic analyte recognition, emphasizing their structural design, sensing mechanisms, and practical applications. The interplay between Schiff base frameworks and ESIPT dynamics enhances signal transduction, enabling the visual and fluorescence-based detection of toxic analytes and other environmental pollutants. The review also explores emerging trends in receptor development, including multi-analyte detection, real-time monitoring, and bioimaging applications. A comparative analysis of various Schiff base sensors highlights their selectivity, detection limits, and practical usability in environmental and biological systems. This comprehensive overview aims to provide insights into the future design of ESIPT-driven Schiff base receptors for enhanced toxic analyte detection and environmental monitoring.

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来源期刊

Journal of Fluorescence 化学-分析化学

CiteScore

4.60

自引率

7.40%

发文量

203

审稿时长

5.4 months

期刊介绍： Journal of Fluorescence is an international forum for the publication of peer-reviewed original articles that advance the practice of this established spectroscopic technique. Topics covered include advances in theory/and or data analysis, studies of the photophysics of aromatic molecules, solvent, and environmental effects, development of stationary or time-resolved measurements, advances in fluorescence microscopy, imaging, photobleaching/recovery measurements, and/or phosphorescence for studies of cell biology, chemical biology and the advanced uses of fluorescence in flow cytometry/analysis, immunology, high throughput screening/drug discovery, DNA sequencing/arrays, genomics and proteomics. Typical applications might include studies of macromolecular dynamics and conformation, intracellular chemistry, and gene expression. The journal also publishes papers that describe the synthesis and characterization of new fluorophores, particularly those displaying unique sensitivities and/or optical properties. In addition to original articles, the Journal also publishes reviews, rapid communications, short communications, letters to the editor, topical news articles, and technical and design notes.