Addressing the challenges of infectious bone defects: a review of recent advances in bifunctional biomaterials.

IF 10.6 1区 生物学 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY
Huaiyuan Zhang, Wenyu Qiao, Yu Liu, Xizhou Yao, Yonghua Zhai, Longhai Du
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引用次数: 0

Abstract

Infectious bone defects present a substantial clinical challenge due to the complex interplay between infection control and bone regeneration. These defects often result from trauma, autoimmune diseases, infections, or tumors, requiring a nuanced approach that simultaneously addresses infection and promotes tissue repair. Recent advances in tissue engineering and materials science, particularly in nanomaterials and nano-drug formulations, have led to the development of bifunctional biomaterials with combined osteogenic and antibacterial properties. These materials offer an alternative to traditional bone grafts, minimizing complications such as multiple surgeries, high antibiotic dosages, and lengthy recovery periods. This review examines the repair mechanisms in the infectious microenvironment and highlights various bifunctional biomaterials that foster both anti-infective and osteogenic processes. Emerging design strategies are also discussed to provide a forward-looking perspective on treating infectious bone defects with clinically significant outcomes.

解决感染性骨缺损的挑战:双功能生物材料的最新进展综述。
由于感染控制和骨再生之间复杂的相互作用,感染性骨缺损呈现出实质性的临床挑战。这些缺陷通常是由创伤、自身免疫性疾病、感染或肿瘤引起的,需要一种微妙的方法来同时解决感染和促进组织修复。组织工程和材料科学的最新进展,特别是在纳米材料和纳米药物配方方面,已经导致了具有成骨和抗菌特性的双功能生物材料的发展。这些材料提供了传统骨移植的替代方案,最大限度地减少了并发症,如多次手术、高抗生素剂量和漫长的恢复期。这篇综述探讨了感染微环境中的修复机制,并强调了各种双功能生物材料,促进抗感染和成骨过程。新兴的设计策略也进行了讨论,以提供具有临床意义的治疗感染性骨缺损前瞻性的观点。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Journal of Nanobiotechnology
Journal of Nanobiotechnology BIOTECHNOLOGY & APPLIED MICROBIOLOGY-NANOSCIENCE & NANOTECHNOLOGY
CiteScore
13.90
自引率
4.90%
发文量
493
审稿时长
16 weeks
期刊介绍: Journal of Nanobiotechnology is an open access peer-reviewed journal communicating scientific and technological advances in the fields of medicine and biology, with an emphasis in their interface with nanoscale sciences. The journal provides biomedical scientists and the international biotechnology business community with the latest developments in the growing field of Nanobiotechnology.
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