Personalized prediction of esophageal cancer risk based on virtually generated alcohol data.

IF 6.1 2区 医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL
Oswald Ndi Nfor, Pei-Ming Huang, Ming-Fang Wu, Ke-Cheng Chen, Ying-Hsiang Chou, Mong-Wei Lin, Ji-Han Zhong, Shuenn-Wen Kuo, Yu-Kwang Lee, Chih-Hung Hsu, Jang-Ming Lee, Yung-Po Liaw
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引用次数: 0

Abstract

Background: Esophageal cancer (EC) presents a significant public health challenge globally, particularly in regions with high alcohol consumption. Its etiology is multifactorial, involving both genetic predispositions and lifestyle factors.

Methods: This study aimed to develop a personalized risk prediction model for EC by integrating genetic polymorphisms (rs671 and rs1229984) with virtually generated alcohol consumption data, utilizing advanced artificial intelligence and machine learning techniques. We analyzed data from 86,845 individuals, including 763 diagnosed EC patients, sourced from the Taiwan Biobank. Eight machine learning models were employed: Bayesian Network, Decision Tree, Ensemble, Gradient Boosting, Logistic Regression, LASSO, Random Forest, and Support Vector Machines (SVM). A unique aspect of our approach was the virtual generation of alcohol consumption data, allowing us to evaluate risk profiles under both consuming and non-consuming scenarios.

Results: Our analysis revealed that individuals with the genotypes rs671 = AG and rs1229984 = CC exhibited the highest probabilities of developing EC, with values ranging from 0.2041 to 0.9181. Notably, abstaining from alcohol could decrease their risk by approximately 16.29-49.58%. The Ensemble model demonstrated exceptional performance, achieving an area under the curve (AUC) of 0.9577 and a sensitivity of 0.9211. This transition from consumption to abstinence indicated a potential risk reduction of nearly 50% for individuals with high-risk genotypes.

Conclusion: Overall, our findings highlight the importance of integrating virtually generated alcohol data for more precise personalized risk assessments for EC.

基于虚拟生成的酒精数据的食管癌风险个性化预测。
背景:食管癌(EC)在全球范围内是一个重大的公共卫生挑战,特别是在酒精消费量高的地区。其病因是多因素的,包括遗传易感性和生活方式因素。方法:本研究旨在利用先进的人工智能和机器学习技术,将遗传多态性(rs671和rs1229984)与虚拟生成的酒精消费数据相结合,建立个性化的EC风险预测模型。我们分析了86,845名个体的数据,其中包括763名诊断为EC的患者,数据来自台湾生物样本库。采用了8种机器学习模型:贝叶斯网络、决策树、集成、梯度增强、逻辑回归、LASSO、随机森林和支持向量机(SVM)。我们方法的一个独特方面是酒精消费数据的虚拟生成,使我们能够评估消费和非消费情景下的风险概况。结果:rs671 = AG和rs1229984 = CC基因型的个体发生EC的概率最高,值为0.2041 ~ 0.9181。值得注意的是,戒酒可以将其风险降低约16.29-49.58%。集成模型表现出优异的性能,曲线下面积(AUC)为0.9577,灵敏度为0.9211。这种从消费到戒断的转变表明高风险基因型个体的潜在风险降低了近50%。结论:总的来说,我们的研究结果强调了整合虚拟生成的酒精数据对EC更精确的个性化风险评估的重要性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Journal of Translational Medicine
Journal of Translational Medicine 医学-医学:研究与实验
CiteScore
10.00
自引率
1.40%
发文量
537
审稿时长
1 months
期刊介绍: The Journal of Translational Medicine is an open-access journal that publishes articles focusing on information derived from human experimentation to enhance communication between basic and clinical science. It covers all areas of translational medicine.
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