Relationship between Helicobacter pylori and hypertriglyceridemia in the population.

IF 3.6 3区 医学 Q2 PHARMACOLOGY & PHARMACY
Yi Chen, Yi Wang, Bingqian Ni, Guoli Ying, Jinshun Zhang
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引用次数: 0

Abstract

Background: Hypertriglyceridemia (HTG) is a prevalent metabolic disorder closely linked to cardiovascular diseases, diabetes, and other metabolic conditions. However, research examining the relationship between Helicobacter pylori (H. pylori) and HTG is limited. This study aimed to investigate the influence of H. pylori on HTG.

Methods: The study participants were individuals who underwent health examinations at Taizhou Hospital between 2017 and 2024. The subjects underwent hematological tests, anthropometric measurements, and urea breath tests. Logistic regression analysis was used to assess the relationship between H. pylori and HTG. Kaplan-Meier curves were utilized to compare HTG incidence between groups, and Cox regression models were applied to calculate associated hazard ratios.

Results: Logistic regression confirmed that H. pylori was a risk factor for HTG. Further cohort study indicated that prolonged H. pylori infection increased the risk of HTG, whereas H. pylori eradication led to a decrease in HTG incidence. Subgroup analyses demonstrated that the impact of H. pylori on HTG did not exhibit heterogeneity.

Conclusion: H. pylori was associated with an increased risk of HTG, and its eradication was crucial for reducing this risk.

幽门螺杆菌与人群高甘油三酯血症的关系。
背景:高甘油三酯血症(HTG)是一种普遍的代谢性疾病,与心血管疾病、糖尿病和其他代谢疾病密切相关。然而,关于幽门螺杆菌(h.p ylori)与HTG之间关系的研究有限。本研究旨在探讨幽门螺旋杆菌对HTG的影响。方法:研究对象为2017 - 2024年间在台州医院接受健康检查的个体。受试者接受血液学测试、人体测量和尿素呼吸测试。采用Logistic回归分析评估幽门螺杆菌与HTG的关系。采用Kaplan-Meier曲线比较各组间HTG发生率,采用Cox回归模型计算相关风险比。结果:Logistic回归证实幽门螺旋杆菌是HTG的危险因素。进一步的队列研究表明,延长幽门螺杆菌感染可增加HTG的风险,而根除幽门螺杆菌可降低HTG的发生率。亚组分析显示幽门螺杆菌对HTG的影响不存在异质性。结论:幽门螺杆菌与HTG风险增加有关,根除幽门螺杆菌对降低HTG风险至关重要。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
7.00
自引率
6.80%
发文量
209
审稿时长
49 days
期刊介绍: Because the scope of clinical lipidology is broad, the topics addressed by the Journal are equally diverse. Typical articles explore lipidology as it is practiced in the treatment setting, recent developments in pharmacological research, reports of treatment and trials, case studies, the impact of lifestyle modification, and similar academic material of interest to the practitioner. Sections of Journal of clinical lipidology will address pioneering studies and the clinicians who conduct them, case studies, ethical standards and conduct, professional guidance such as ATP and NCEP, editorial commentary, letters from readers, National Lipid Association (NLA) news and upcoming event information, as well as abstracts from the NLA annual scientific sessions and the scientific forums held by its chapters, when appropriate.
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