Risk of Advanced Adenomas in Siblings Aged ≤ 50 Years of Patients with Early-Onset Colorectal Advanced Adenomas.

IF 2.5 4区医学 Q2 GASTROENTEROLOGY & HEPATOLOGY

Digestive Diseases and Sciences Pub Date : 2025-03-29 DOI:10.1007/s10620-025-09014-x

Luan Minh Dang, Nhan Quang Le, Huy Minh Le, Diem Thi-Ngoc Vo, Nguyen Lam Vuong, Minh Cuong Duong, Duc Trong Quach

{"title":"Risk of Advanced Adenomas in Siblings Aged ≤ 50 Years of Patients with Early-Onset Colorectal Advanced Adenomas.","authors":"Luan Minh Dang, Nhan Quang Le, Huy Minh Le, Diem Thi-Ngoc Vo, Nguyen Lam Vuong, Minh Cuong Duong, Duc Trong Quach","doi":"10.1007/s10620-025-09014-x","DOIUrl":null,"url":null,"abstract":"Purpose: The risk of colorectal advanced adenomas (CAAs) and colorectal cancer (CRC) in siblings aged ≤ 50 of patients diagnosed with early-onset CAAs (E-CAAs), defined as having CAA at or below 50 years, is poorly understood. This study examined the risks of adenomas, CAA, and CRC in siblings aged ≤ 50 of patients diagnosed with E-CAA.Methods: This case-control study was conducted at a tertiary hospital in Vietnam. The participants included 96 cases who were siblings aged ≤ 50 of patients diagnosed with E-CAA. Controls were randomly selected from consecutive patients aged ≤ 50 who did not have siblings diagnosed with E-CAA. Controls were matched to cases in a 2:1 ratio for age, sex, and smoking status.Results: The mean age was similar between cases (40.9 ± 6.0 years) and controls (41.1 ± 6.0 years). Except for indications for colonoscopy, there were no significant differences in the baseline demographics between the two groups. A heightened risk of CAA was documented in cases compared with controls (odds ratio [OR] 6.33; 95% confidence interval [CI] 1.43-43.8; P = 0.018). This increased risk was more pronounced in males (OR 13.7; 95% CI 1.23-262; P = 0.006). Cases had higher risks of colorectal adenomas (OR 2.43; 95% CI 1.27-4.67; P = 0.009) and colorectal neoplasia (OR 2.33; 95% CI 1.24-4.40; P = 0.011) than those in controls.Conclusion: Siblings aged ≤ 50 of patients diagnosed with E-CAA have an increased risk of adenomas, CAA, and colorectal neoplasia. CRC screening should be initiated early in these high-risk individuals.","PeriodicalId":11378,"journal":{"name":"Digestive Diseases and Sciences","volume":" ","pages":""},"PeriodicalIF":2.5000,"publicationDate":"2025-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Digestive Diseases and Sciences","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s10620-025-09014-x","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"GASTROENTEROLOGY & HEPATOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Purpose: The risk of colorectal advanced adenomas (CAAs) and colorectal cancer (CRC) in siblings aged ≤ 50 of patients diagnosed with early-onset CAAs (E-CAAs), defined as having CAA at or below 50 years, is poorly understood. This study examined the risks of adenomas, CAA, and CRC in siblings aged ≤ 50 of patients diagnosed with E-CAA.

Methods: This case-control study was conducted at a tertiary hospital in Vietnam. The participants included 96 cases who were siblings aged ≤ 50 of patients diagnosed with E-CAA. Controls were randomly selected from consecutive patients aged ≤ 50 who did not have siblings diagnosed with E-CAA. Controls were matched to cases in a 2:1 ratio for age, sex, and smoking status.

Results: The mean age was similar between cases (40.9 ± 6.0 years) and controls (41.1 ± 6.0 years). Except for indications for colonoscopy, there were no significant differences in the baseline demographics between the two groups. A heightened risk of CAA was documented in cases compared with controls (odds ratio [OR] 6.33; 95% confidence interval [CI] 1.43-43.8; P = 0.018). This increased risk was more pronounced in males (OR 13.7; 95% CI 1.23-262; P = 0.006). Cases had higher risks of colorectal adenomas (OR 2.43; 95% CI 1.27-4.67; P = 0.009) and colorectal neoplasia (OR 2.33; 95% CI 1.24-4.40; P = 0.011) than those in controls.

Conclusion: Siblings aged ≤ 50 of patients diagnosed with E-CAA have an increased risk of adenomas, CAA, and colorectal neoplasia. CRC screening should be initiated early in these high-risk individuals.

查看原文本刊更多论文

年龄≤50岁的兄弟姐妹早发性结直肠癌晚期腺瘤的风险

目的：对于被诊断为早发CAA（E-CAA）患者（定义为在50岁或50岁以下患有CAA）的年龄≤50岁的兄弟姐妹患结直肠晚期腺瘤（CAA）和结直肠癌（CRC）的风险，目前还知之甚少。本研究探讨了确诊为 E-CAA 患者的 50 岁以下兄弟姐妹患腺瘤、CAA 和 CRC 的风险：这项病例对照研究在越南一家三级医院进行。方法：这项病例对照研究在越南的一家三甲医院进行，共有 96 例病例，他们都是被诊断为 E-CAA 患者的年龄不超过 50 岁的兄弟姐妹。对照组是从年龄小于 50 岁且没有兄弟姐妹被确诊为 E-CAA 的连续患者中随机抽取的。对照组与病例的年龄、性别和吸烟状况按2:1的比例匹配：病例（40.9 ± 6.0 岁）和对照组（41.1 ± 6.0 岁）的平均年龄相似。除结肠镜检查适应症外，两组患者的基线人口统计学特征无明显差异。与对照组相比，病例患 CAA 的风险更高（几率比 [OR] 6.33；95% 置信区间 [CI] 1.43-43.8；P = 0.018）。男性的风险增加更为明显（OR 13.7；95% CI 1.23-262；P = 0.006）。与对照组相比，病例患结直肠腺瘤（OR 2.43；95% CI 1.27-4.67；P = 0.009）和结直肠肿瘤（OR 2.33；95% CI 1.24-4.40；P = 0.011）的风险更高：结论：被诊断为E-CAA患者的年龄≤50岁的兄弟姐妹患腺瘤、CAA和结直肠肿瘤的风险增加。对这些高危人群应及早进行结直肠癌筛查。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Digestive Diseases and Sciences 医学-胃肠肝病学

CiteScore

6.40

自引率

3.20%

发文量

420

审稿时长

1 months

期刊介绍： Digestive Diseases and Sciences publishes high-quality, peer-reviewed, original papers addressing aspects of basic/translational and clinical research in gastroenterology, hepatology, and related fields. This well-illustrated journal features comprehensive coverage of basic pathophysiology, new technological advances, and clinical breakthroughs; insights from prominent academicians and practitioners concerning new scientific developments and practical medical issues; and discussions focusing on the latest changes in local and worldwide social, economic, and governmental policies that affect the delivery of care within the disciplines of gastroenterology and hepatology.