Healthy lifestyle indices are associated with breast cancer immunophenotypes in women

IF 2.9 Q3 NUTRITION & DIETETICS

Clinical nutrition ESPEN Pub Date : 2025-03-26 DOI:10.1016/j.clnesp.2025.03.031

Brianda Armenta-Guirado , Ángel Mérida-Ortega , Lizbeth López-Carrillo , Edgar Denova-Gutiérrez

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引用次数: 0

Abstract

Background

Multiple modifiable lifestyle risk factors are independently associated with breast cancer (BC); however, evidence lacks regarding the joint relationship between lifestyle components and BC immunophenotypes.

Aim

We aimed to assess the association among adherence to healthy lifestyle indices and BC immunophenotypes in women.

Methods

We conducted a secondary analysis of data from a study performed between 2007 and 2011, comprising 1045 cases and 1030 population controls. We retrieved information on estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor 2 (HER2) expression from medical records to classify BC as luminal (ER+ and/or PR+/HER2–), HER2+ (ER+/− and/or PR+/−/HER2+), or triple negative (TN) (ER– and PR–/HER2–). Through direct interviews, we obtained lifestyle variable information such as diet, physical activity, as well as tobacco and alcohol consumption. We evaluated compliance with the Healthy Lifestyle Index Score (HLIS) and the Healthy Behavior Index (HBI). We used non-conditional logistic regression models to assess the association between BC immunophenotypes and the indices.

Results

Women with higher adherence to the HLIS had a 23 % lower probability of BC (Odds ratio [OR]_{Tertil (T)3vsT1} = 0.77; 95%Confidence Interval [CI]: 0.60, 0.99; p-trend = 0.030), while those adhering to the HBI showed a 68 % reduction (OR _T3vsT1 = 0.32; 95%CI: 0.24, 0.42; p-trend = 0.000). These associations remained negative across all BC immunophenotypes.

Conclusion

Adherence to healthy lifestyle indices might prevent BC. Further research is warranted to elucidate the intricate interplay among lifestyle factors and BC risk across diverse populations and immunophenotypes.

查看原文本刊更多论文

健康生活方式指数与女性乳腺癌免疫表型有关。

背景：多种可改变的生活方式危险因素与乳腺癌（BC）独立相关；然而，缺乏关于生活方式成分与BC免疫表型之间联合关系的证据。目的：我们的目的是评估妇女坚持健康生活方式指数和BC免疫表型之间的关系。方法：我们对2007年至2011年间进行的一项研究的数据进行了二次分析，其中包括1,045例病例和1,030例人口对照。我们从医疗记录中检索了雌激素受体（ER）、孕激素受体（PR）和人表皮生长因子2 （HER2）的表达信息，将BC分为luminal （ER+和/或PR+/HER2-）、HER2+ （ER+/-和/或PR+/-/HER2+）或三阴性（TN）（ER-和PR-/HER2-）。通过直接访谈，我们获得了生活方式的可变信息，如饮食、体育活动以及烟酒消费。我们评估了健康生活方式指数评分（HLIS）和健康行为指数（HBI）的依从性。我们使用非条件逻辑回归模型来评估BC免疫表型与这些指标之间的关系。结果：高依从性HLIS的女性患BC的可能性降低23%(优势比[OR] terir (T)3vsT1=0.77；95%置信区间[CI]: 0.60, 0.99；p-trend = 0.030)，而坚持HBI的患者则减少68% (OR T3vsT1=0.32；95%ci: 0.24, 0.42；P-trend = 0.000)。这些关联在所有BC免疫表型中均为阴性。结论：坚持健康生活方式指标可预防BC。在不同的人群和免疫表型中，需要进一步的研究来阐明生活方式因素与BC风险之间复杂的相互作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical nutrition ESPEN NUTRITION & DIETETICS-

CiteScore

4.90

自引率

3.30%

发文量

512

期刊介绍： Clinical Nutrition ESPEN is an electronic-only journal and is an official publication of the European Society for Clinical Nutrition and Metabolism (ESPEN). Nutrition and nutritional care have gained wide clinical and scientific interest during the past decades. The increasing knowledge of metabolic disturbances and nutritional assessment in chronic and acute diseases has stimulated rapid advances in design, development and clinical application of nutritional support. The aims of ESPEN are to encourage the rapid diffusion of knowledge and its application in the field of clinical nutrition and metabolism. Published bimonthly, Clinical Nutrition ESPEN focuses on publishing articles on the relationship between nutrition and disease in the setting of basic science and clinical practice. Clinical Nutrition ESPEN is available to all members of ESPEN and to all subscribers of Clinical Nutrition.