{"title":"Comparing the maternal and neonatal outcomes in vaccinated and unvaccinated pregnant women against COVID-19: a retrospective cohort study.","authors":"Zahra Gholami, Maryam Mohseni, Pouran Allahbakhshi Nasab","doi":"10.1186/s12884-025-07462-x","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Following the emergence of COVID-19 disease, and considering the limited number of studies regarding vaccination among pregnant women, as well as the differences between the vaccine administered in Iran and those used in other countries, this study aimed to compare maternal and neonatal outcomes in vaccinated and unvaccinated women against COVID-19 disease.</p><p><strong>Methods: </strong>This retrospective cohort study was conducted at the comprehensive healthcare centers of Rafsanjan city. Initially, the contact information of expectant mothers who were pregnant between June 22, 2021, and December 22, 2021, was obtained through Iran's integrated healthcare system (Sib). Subsequently, the required information was collected via a checklist during phone interviews. Out of 969 pregnant women, after applying the inclusion and exclusion criteria, 610 subjects were included in the study. Among these, 330 were unvaccinated, while the remaining participants had received the inactivated COVID-19 vaccine prior to or during pregnancy. Maternal and neonatal outcomes were compared between vaccinated and unvaccinated women. Data analysis was performed using SPSS version 26, employing one-way analysis of variance (ANOVA), Tukey's multiple comparison test, Fisher's exact test, Chi-square test, and multiple logistic regression.</p><p><strong>Results: </strong>The findings indicated that vaccination against COVID-19 in pregnant women significantly increased the risk of neonatal jaundice (P < 0.05). Conversely, the miscarriage rate among these women was significantly lower (P < 0.05). No adverse outcomes were observed including hypertensive disorders, gestational diabetes, maternal hospitalization, maternal COVID-19 infection, preterm labor, premature rupture of membranes, perinatal mortality, admission to the neonatal intensive care unit, and low birth weight.</p><p><strong>Conclusions: </strong>COVID-19 Vaccination is recommended for pregnant women to mitigate adverse neonatal and maternal outcomes.</p>","PeriodicalId":9033,"journal":{"name":"BMC Pregnancy and Childbirth","volume":"25 1","pages":"367"},"PeriodicalIF":2.8000,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11951651/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"BMC Pregnancy and Childbirth","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1186/s12884-025-07462-x","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"OBSTETRICS & GYNECOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Background: Following the emergence of COVID-19 disease, and considering the limited number of studies regarding vaccination among pregnant women, as well as the differences between the vaccine administered in Iran and those used in other countries, this study aimed to compare maternal and neonatal outcomes in vaccinated and unvaccinated women against COVID-19 disease.
Methods: This retrospective cohort study was conducted at the comprehensive healthcare centers of Rafsanjan city. Initially, the contact information of expectant mothers who were pregnant between June 22, 2021, and December 22, 2021, was obtained through Iran's integrated healthcare system (Sib). Subsequently, the required information was collected via a checklist during phone interviews. Out of 969 pregnant women, after applying the inclusion and exclusion criteria, 610 subjects were included in the study. Among these, 330 were unvaccinated, while the remaining participants had received the inactivated COVID-19 vaccine prior to or during pregnancy. Maternal and neonatal outcomes were compared between vaccinated and unvaccinated women. Data analysis was performed using SPSS version 26, employing one-way analysis of variance (ANOVA), Tukey's multiple comparison test, Fisher's exact test, Chi-square test, and multiple logistic regression.
Results: The findings indicated that vaccination against COVID-19 in pregnant women significantly increased the risk of neonatal jaundice (P < 0.05). Conversely, the miscarriage rate among these women was significantly lower (P < 0.05). No adverse outcomes were observed including hypertensive disorders, gestational diabetes, maternal hospitalization, maternal COVID-19 infection, preterm labor, premature rupture of membranes, perinatal mortality, admission to the neonatal intensive care unit, and low birth weight.
Conclusions: COVID-19 Vaccination is recommended for pregnant women to mitigate adverse neonatal and maternal outcomes.
背景：在COVID-19疾病出现后，考虑到关于孕妇接种疫苗的研究数量有限，以及伊朗接种的疫苗与其他国家使用的疫苗之间的差异，本研究旨在比较接种疫苗和未接种疫苗的妇女预防COVID-19疾病的孕产妇和新生儿结局。方法：回顾性队列研究在拉夫桑詹市综合保健中心进行。最初，通过伊朗综合医疗保健系统（Sib）获得了2021年6月22日至2021年12月22日期间怀孕的孕妇的联系信息。随后，在电话访谈期间通过清单收集所需信息。在969名孕妇中，应用纳入和排除标准后，有610名受试者被纳入研究。其中330人未接种疫苗，其余参与者在怀孕前或怀孕期间接种了COVID-19灭活疫苗。比较了接种疫苗和未接种疫苗的妇女的孕产妇和新生儿结局。数据分析采用SPSS version 26，采用单因素方差分析（ANOVA）、Tukey多重比较检验、Fisher精确检验、卡方检验和多元logistic回归。结果：研究结果显示，孕妇接种COVID-19疫苗可显著增加新生儿黄疸的风险(P)。结论：建议孕妇接种COVID-19疫苗，以减轻新生儿和孕产妇的不良结局。
期刊介绍：
BMC Pregnancy & Childbirth is an open access, peer-reviewed journal that considers articles on all aspects of pregnancy and childbirth. The journal welcomes submissions on the biomedical aspects of pregnancy, breastfeeding, labor, maternal health, maternity care, trends and sociological aspects of pregnancy and childbirth.
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