Hepatobiliary phase manifestations of breast cancer liver metastasis: differentiating molecular types through Gd-EOB-DTPA-enhanced MRI.

IF 2.9 3区医学 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

BMC Medical Imaging Pub Date : 2025-03-28 DOI:10.1186/s12880-025-01648-7

Hui Jiang, Jin-Rong Qu, Li-Feng Wang, Peng-Rui Gao, Bing-Jie Zheng, Hong-Kai Zhang, Li-Na Jiang

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引用次数: 0

Abstract

Objective: The primary objective of this study is to evaluate the diagnostic efficacy of gadolinium ethoxybenzyl diethylenetriaminepentaacetic acid (Gd-EOB-DTPA) -enhanced magnetic resonance imaging (MRI) in distinguishing breast cancer liver metastasis (BCLM) across different molecular types.

Methods: Between August 2014 and July 2021, a cohort of 270 patients histologically diagnosed with BCLM underwent examination through dynamic contrast-enhanced MRI (DCE-MRI). The data collection encompassed clinical information of patients, as well as information on the quantity, shape, boundary, and fusion state of liver metastases. Additionally, MR sequences including T2-weighted imaging with fat suppression (FS), diffusion-weighted imaging (DWI), MR arterial phase, and hepatobiliary phase (HBP) were collected. The chi-squared test was employed to study the correlations between different molecular types of BCLM and imaging features observed in MRI.

Results: Significant differences were observed in the HBP image features among various subtypes of breast cancer (P = 0.022). The morphology (oval, irregular) and fusion state (converging, separated lesions) of BCLM exhibited statistically significant differences based on breast cancer subtypes (P = 0.022, 0.004). No statistical differences were found in the quantity of BCLM, the boundary of metastasis (clear or vague), and imaging features of the T2WI-FS and DWI concerning the molecular subtypes of BCLM (P = 0.693, 0.161, 0.629, 0.629).

Conclusion: The findings suggest that MRI, particularly Gd-EOB-DTPA-enhanced MRI, they displayed varied enhancement patterns, including the low signal, "target sign", "rim enhancement", and "doughnut-like enhancement". Most basal-like metastases demonstrated a low signal, the other molecular types primarily showing the "target sign". This is invaluable in the imaging diagnosis of BCLM across different molecular type.

Clinical trial number: Not applicable.

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研究目的本研究的主要目的是评估钆乙氧苄基二乙烯三胺五乙酸（Gd-EOB-DTPA）增强磁共振成像（MRI）在区分不同分子类型的乳腺癌肝转移（BCLM）方面的诊断效果：2014年8月至2021年7月期间，270名经组织学诊断为BCLM的患者接受了动态对比增强磁共振成像（DCE-MRI）检查。数据收集包括患者的临床信息，以及肝转移灶的数量、形状、边界和融合状态等信息。此外，还收集了包括带脂肪抑制（FS）的 T2 加权成像、弥散加权成像（DWI）、磁共振动脉期和肝胆期（HBP）在内的磁共振序列。采用卡方检验研究 BCLM 不同分子类型与 MRI 观察到的成像特征之间的相关性：结果：不同亚型乳腺癌的 HBP 图像特征存在显著差异（P = 0.022）。不同亚型乳腺癌的 BCLM 形态（椭圆形、不规则形）和融合状态（融合、分离病灶）差异有统计学意义（P = 0.022，0.004）。BCLM的数量、转移边界（清晰或模糊）以及T2WI-FS和DWI的成像特征与BCLM的分子亚型无统计学差异（P = 0.693，0.161，0.629，0.629）：研究结果表明，核磁共振成像，尤其是 Gd-EOB-DTPA 增强核磁共振成像，显示出不同的增强模式，包括低信号、"靶标征"、"边缘强化 "和 "甜甜圈样强化"。大多数基底样转移灶表现为低信号，其他分子类型主要表现为 "靶标征"。这对不同分子类型的BCLM的影像诊断非常有价值：临床试验编号：不适用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

BMC Medical Imaging RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING-

CiteScore

4.60

自引率

3.70%

发文量

198

审稿时长

27 weeks

期刊介绍： BMC Medical Imaging is an open access journal publishing original peer-reviewed research articles in the development, evaluation, and use of imaging techniques and image processing tools to diagnose and manage disease.