Sub-chronic level FLX exposure and biomarker response in Labeo rohita.

IF 2.4 4区环境科学与生态学 Q2 ECOLOGY

Ecotoxicology Pub Date : 2025-03-29 DOI:10.1007/s10646-025-02881-0

M Sujitha, K Manimegalai

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引用次数: 0

Abstract

Selective serotonin reuptake inhibitors (SSRIs) are among the most widely prescribed psychotropic medications globally used to treat depression, anxiety disorders, and related mental health conditions. Among these, Fluoxetine (FLX), recognized by its brand name Prozac, is frequently used. SSRIs increase serotonin levels in the brain, inhibiting its reuptake to enhance mood and emotional stability. However, their widespread production, consumption, and eventual environmental release are raising concerns among aquatic toxicologists and environmental biologists due to their potential impact on ecosystems and human health. This study investigated the long-term (35-days) antioxidant responses in Labeo rohita fingerlings exposed to varying concentrations of FLX (1, 10, and 100 μg/L). Compared to control groups, the activity of superoxide dismutase (SOD) in the brain significantly decreased (P < 0.05) in FLX-treated fish, except at the highest (100 μg/L) concentration on the 35^th day. Similarly, catalase (CAT) and glutathione S-transferase (GST) activity were significantly reduced (P < 0.05) across all treatments. Lipid peroxidation (LPO) levels were markedly elevated in FLX-treated fishes, signifying oxidative stress. Acetylcholinesterase activity in brain tissue decreased in FLX-treated groups. These findings provide critical baseline data for molecular toxicology, highlighting the potential effects of pharmaceutical pollutants on non-target aquatic organisms.

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亚慢性水平的FLX暴露和动物标志物反应。

选择性血清素再摄取抑制剂（SSRIs）是全球最广泛使用的精神药物之一，用于治疗抑郁症、焦虑症和相关精神健康状况。其中，氟西汀（FLX），以其品牌名称百忧解而闻名，是常用的药物。SSRIs增加大脑中的血清素水平，抑制其再吸收，从而增强情绪和情绪稳定性。然而，由于它们对生态系统和人类健康的潜在影响，它们的广泛生产、消费和最终的环境释放引起了水生毒理学家和环境生物学家的关注。本研究研究了暴露于不同浓度FLX（1、10和100 μg/L）下的罗氏Labeo rohita鱼种的长期（35 d）抗氧化反应。与对照组相比，第P天大鼠脑组织超氧化物歧化酶（SOD）活性显著降低。过氧化氢酶（CAT）和谷胱甘肽s -转移酶（GST）活性也显著降低(P

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来源期刊

Ecotoxicology 环境科学-毒理学

CiteScore

5.30

自引率

3.70%

发文量

107

审稿时长

4.7 months

期刊介绍： Ecotoxicology is an international journal devoted to the publication of fundamental research on the effects of toxic chemicals on populations, communities and terrestrial, freshwater and marine ecosystems. It aims to elucidate mechanisms and processes whereby chemicals exert their effects on ecosystems and the impact caused at the population or community level. The journal is not biased with respect to taxon or biome, and papers that indicate possible new approaches to regulation and control of toxic chemicals and those aiding in formulating ways of conserving threatened species are particularly welcome. Studies on individuals should demonstrate linkage to population effects in clear and quantitative ways. Laboratory studies must show a clear linkage to specific field situations. The journal includes not only original research papers but technical notes and review articles, both invited and submitted. A strong, broadly based editorial board ensures as wide an international coverage as possible.