Hijacking JAKis: JAK inhibitors as potential antiviral molecules, a mini review

IF 4.5 2区医学 Q1 PHARMACOLOGY & PHARMACY

Antiviral research Pub Date : 2025-03-27 DOI:10.1016/j.antiviral.2025.106153

Claudie Eber, Eloi R. Verrier

引用次数: 0

Abstract

Janus kinases (JAKs) are key players in the innate immune response and inflammation, catalysing the phosphorylation of STAT proteins, which ultimately leads to the expression of pro-inflammatory and antimicrobial genes. In this context, specific inhibitors of JAK kinases, or JAKis, have been extensively developed, with some already in clinical use for the treatment of chronic inflammatory diseases. However, the interactions between JAK kinases and viral replication appear to be far more complex than initially expected, with some JAKis showing unexpected antiviral properties against different classes of viruses. This mini review summarizes current knowledge about the interactions between JAK proteins and viral infections and discusses the antiviral potential of JAK inhibitors in the development of innovative therapeutic strategies.

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劫持JAKis：作为潜在抗病毒分子的JAK抑制剂，综述。

Janus激酶（JAKs）是先天免疫反应和炎症的关键参与者，它催化STAT蛋白的磷酸化，最终导致促炎和抗菌基因的表达。在此背景下，JAK激酶的特异性抑制剂（或JAKis）已被广泛开发，其中一些已用于临床治疗慢性炎症性疾病。然而，JAK激酶和病毒复制之间的相互作用似乎比最初预期的要复杂得多，一些JAKis对不同类型的病毒表现出意想不到的抗病毒特性。这篇综述总结了目前关于JAK蛋白与病毒感染之间相互作用的知识，并讨论了JAK抑制剂在开发创新治疗策略中的抗病毒潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Antiviral research 医学-病毒学

CiteScore

17.10

自引率

3.90%

发文量

157

审稿时长

34 days

期刊介绍： Antiviral Research is a journal that focuses on various aspects of controlling viral infections in both humans and animals. It is a platform for publishing research reports, short communications, review articles, and commentaries. The journal covers a wide range of topics including antiviral drugs, antibodies, and host-response modifiers. These topics encompass their synthesis, in vitro and in vivo testing, as well as mechanisms of action. Additionally, the journal also publishes studies on the development of new or improved vaccines against viral infections in humans. It delves into assessing the safety of drugs and vaccines, tracking the evolution of drug or vaccine-resistant viruses, and developing effective countermeasures. Another area of interest includes the identification and validation of new drug targets. The journal further explores laboratory animal models of viral diseases, investigates the pathogenesis of viral diseases, and examines the mechanisms by which viruses avoid host immune responses.