Hyperfructosaminemia in alpacas (Vicugna pacos) is associated with hyperglycemia, hypofructosaminemia with decreased plasma proteins, and poor nutritional status.
Matthias Gerhard Wagener, Johannes Buchallik-Schregel, Petra Röhrig, Max Kornblum, Saskia Neubert, Alexandra von Altrock, Benjamin U Bauer, Thies J Nicolaisen, Martin Ganter, Frederik Kiene
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引用次数: 0
Abstract
Objective: To describe and compare clinical and laboratory findings in alpacas with hypofructosaminemia (fructosamine low [FL]), normofructosaminemia, and hyperfructosaminemia (fructosamine high [FH]) in order to identify associations of abnormal plasma fructosamine (PF) with other clinical and laboratory findings in alpacas.
Methods: A retrospective observational study was conducted with clinical and laboratory data of 125 alpacas with FL (PF < 252 µmol/L; n = 19), normofructosaminemia (PF, 252 to 425 µmol/L; n = 93), and FH (PF > 425 µmol/L; n = 13) presented to a veterinary teaching hospital from January 2022 through January 2023. Findings of the animals were compared using descriptive statistics and comparisons (Kruskal-Wallis test, 1-way ANOVA, t test, or Mann-Whitney U test). Resulting diagnoses were tested for associations with fructosamine using the 2-sided Fisher exact test.
Results: FL occurred more frequently in crias than adults and was associated with lower bodyweight, body condition score, PCV, total protein, albumin, and globulin. Hyperfructosaminemia was associated with hyperglycemia. While a large proportion of the alpacas with FL had cachexia (8 of 19) and/or anemia (6 of 19), the alpacas with FH were given many different diagnoses.
Conclusions: The available data suggest that FH in alpacas is associated with hyperglycemia, whereas FL is associated with decreased plasma proteins and poor nutritional status.
Clinical relevance: PF is rarely used in routine diagnostics in alpacas, but it can aid in the interpretation of plasma glucose, plasma proteins, and nutritional status.
期刊介绍：
The American Journal of Veterinary Research supports the collaborative exchange of information between researchers and clinicians by publishing novel research findings that bridge the gulf between basic research and clinical practice or that help to translate laboratory research and preclinical studies to the development of clinical trials and clinical practice. The journal welcomes submission of high-quality original studies and review articles in a wide range of scientific fields, including anatomy, anesthesiology, animal welfare, behavior, epidemiology, genetics, heredity, infectious disease, molecular biology, oncology, pharmacology, pathogenic mechanisms, physiology, surgery, theriogenology, toxicology, and vaccinology. Species of interest include production animals, companion animals, equids, exotic animals, birds, reptiles, and wild and marine animals. Reports of laboratory animal studies and studies involving the use of animals as experimental models of human diseases are considered only when the study results are of demonstrable benefit to the species used in the research or to another species of veterinary interest. Other fields of interest or animals species are not necessarily excluded from consideration, but such reports must focus on novel research findings. Submitted papers must make an original and substantial contribution to the veterinary medicine knowledge base; preliminary studies are not appropriate.
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