Hyperfructosaminemia in alpacas (Vicugna pacos) is associated with hyperglycemia, hypofructosaminemia with decreased plasma proteins, and poor nutritional status.

IF 1.3 3区农林科学 Q2 VETERINARY SCIENCES

American journal of veterinary research Pub Date : 2025-03-28 DOI:10.2460/ajvr.24.10.0306

Matthias Gerhard Wagener, Johannes Buchallik-Schregel, Petra Röhrig, Max Kornblum, Saskia Neubert, Alexandra von Altrock, Benjamin U Bauer, Thies J Nicolaisen, Martin Ganter, Frederik Kiene

{"title":"Hyperfructosaminemia in alpacas (Vicugna pacos) is associated with hyperglycemia, hypofructosaminemia with decreased plasma proteins, and poor nutritional status.","authors":"Matthias Gerhard Wagener, Johannes Buchallik-Schregel, Petra Röhrig, Max Kornblum, Saskia Neubert, Alexandra von Altrock, Benjamin U Bauer, Thies J Nicolaisen, Martin Ganter, Frederik Kiene","doi":"10.2460/ajvr.24.10.0306","DOIUrl":null,"url":null,"abstract":"Objective: To describe and compare clinical and laboratory findings in alpacas with hypofructosaminemia (fructosamine low [FL]), normofructosaminemia, and hyperfructosaminemia (fructosamine high [FH]) in order to identify associations of abnormal plasma fructosamine (PF) with other clinical and laboratory findings in alpacas.Methods: A retrospective observational study was conducted with clinical and laboratory data of 125 alpacas with FL (PF < 252 µmol/L; n = 19), normofructosaminemia (PF, 252 to 425 µmol/L; n = 93), and FH (PF > 425 µmol/L; n = 13) presented to a veterinary teaching hospital from January 2022 through January 2023. Findings of the animals were compared using descriptive statistics and comparisons (Kruskal-Wallis test, 1-way ANOVA, t test, or Mann-Whitney U test). Resulting diagnoses were tested for associations with fructosamine using the 2-sided Fisher exact test.Results: FL occurred more frequently in crias than adults and was associated with lower bodyweight, body condition score, PCV, total protein, albumin, and globulin. Hyperfructosaminemia was associated with hyperglycemia. While a large proportion of the alpacas with FL had cachexia (8 of 19) and/or anemia (6 of 19), the alpacas with FH were given many different diagnoses.Conclusions: The available data suggest that FH in alpacas is associated with hyperglycemia, whereas FL is associated with decreased plasma proteins and poor nutritional status.Clinical relevance: PF is rarely used in routine diagnostics in alpacas, but it can aid in the interpretation of plasma glucose, plasma proteins, and nutritional status.","PeriodicalId":7754,"journal":{"name":"American journal of veterinary research","volume":" ","pages":"1-8"},"PeriodicalIF":1.3000,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"American journal of veterinary research","FirstCategoryId":"97","ListUrlMain":"https://doi.org/10.2460/ajvr.24.10.0306","RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"VETERINARY SCIENCES","Score":null,"Total":0}

引用次数: 0

Abstract

Objective: To describe and compare clinical and laboratory findings in alpacas with hypofructosaminemia (fructosamine low [FL]), normofructosaminemia, and hyperfructosaminemia (fructosamine high [FH]) in order to identify associations of abnormal plasma fructosamine (PF) with other clinical and laboratory findings in alpacas.

Methods: A retrospective observational study was conducted with clinical and laboratory data of 125 alpacas with FL (PF < 252 µmol/L; n = 19), normofructosaminemia (PF, 252 to 425 µmol/L; n = 93), and FH (PF > 425 µmol/L; n = 13) presented to a veterinary teaching hospital from January 2022 through January 2023. Findings of the animals were compared using descriptive statistics and comparisons (Kruskal-Wallis test, 1-way ANOVA, t test, or Mann-Whitney U test). Resulting diagnoses were tested for associations with fructosamine using the 2-sided Fisher exact test.

Results: FL occurred more frequently in crias than adults and was associated with lower bodyweight, body condition score, PCV, total protein, albumin, and globulin. Hyperfructosaminemia was associated with hyperglycemia. While a large proportion of the alpacas with FL had cachexia (8 of 19) and/or anemia (6 of 19), the alpacas with FH were given many different diagnoses.

Conclusions: The available data suggest that FH in alpacas is associated with hyperglycemia, whereas FL is associated with decreased plasma proteins and poor nutritional status.

Clinical relevance: PF is rarely used in routine diagnostics in alpacas, but it can aid in the interpretation of plasma glucose, plasma proteins, and nutritional status.

查看原文本刊更多论文

羊驼（Vicugna pacos）高果糖胺血症与高血糖、低果糖胺血症伴血浆蛋白降低和营养状况不良有关。

目的：描述和比较羊驼低果糖胺血症（低果糖胺[FL]）、正常果糖胺血症和高果糖胺血症（高果糖胺[FH]）的临床和实验室结果，以确定羊驼血浆中异常果糖胺（PF）与其他临床和实验室结果的关系。方法：采用回顾性观察方法对125头FL (PF < 252µmol/L；n = 19)，正果糖胺血症(PF, 252 ~ 425µmol/L；n = 93), FH (PF bb0 425µmol/L；n = 13)，于2022年1月至2023年1月期间提交给兽医教学医院。采用描述性统计和比较（Kruskal-Wallis检验、单因素方差分析、t检验或Mann-Whitney U检验）对动物的研究结果进行比较。使用双侧Fisher精确检验检测结果诊断与果糖胺的关系。结果：小儿滤泡性淋巴瘤的发生频率高于成人，并且与体重、身体状况评分、PCV、总蛋白、白蛋白和球蛋白较低有关。高果糖胺血症与高血糖有关。虽然有很大比例的羊驼患有恶病质（19例中有8例）和/或贫血（19例中有6例），但患有FH的羊驼得到了许多不同的诊断。结论：现有数据表明，羊驼的FH与高血糖有关，而FL与血浆蛋白降低和营养状况不良有关。临床相关性：PF很少用于羊驼的常规诊断，但它可以帮助解释血浆葡萄糖、血浆蛋白和营养状况。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

American journal of veterinary research 农林科学-兽医学

CiteScore

1.70

自引率

10.00%

发文量

186

审稿时长

3 months

期刊介绍： The American Journal of Veterinary Research supports the collaborative exchange of information between researchers and clinicians by publishing novel research findings that bridge the gulf between basic research and clinical practice or that help to translate laboratory research and preclinical studies to the development of clinical trials and clinical practice. The journal welcomes submission of high-quality original studies and review articles in a wide range of scientific fields, including anatomy, anesthesiology, animal welfare, behavior, epidemiology, genetics, heredity, infectious disease, molecular biology, oncology, pharmacology, pathogenic mechanisms, physiology, surgery, theriogenology, toxicology, and vaccinology. Species of interest include production animals, companion animals, equids, exotic animals, birds, reptiles, and wild and marine animals. Reports of laboratory animal studies and studies involving the use of animals as experimental models of human diseases are considered only when the study results are of demonstrable benefit to the species used in the research or to another species of veterinary interest. Other fields of interest or animals species are not necessarily excluded from consideration, but such reports must focus on novel research findings. Submitted papers must make an original and substantial contribution to the veterinary medicine knowledge base; preliminary studies are not appropriate.