Takumi Kazama, Rachel C Hector, Ann M Hess, Marlis L Rezende
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引用次数: 0
Abstract
Objective: To determine the cardiopulmonary effects of oral trazodone before isoflurane anesthesia in systemically healthy horses.
Methods: 12 horses donated for euthanasia (from August 2022 through June 2023) due to conditions unrelated to the cardiovascular system were included in this prospective, randomized, controlled trial. Horses were assigned to receive oral trazodone (6 mg/kg; n = 7) or corn syrup (n = 5) 1 hour before xylazine (1 mg/kg, IV) sedation, ketamine (2.2 mg/kg, IV) and propofol (0.7 mg/kg, IV) induction, and anesthetic maintenance with inhaled isoflurane (target 1.6% expired) for 75 minutes. Dobutamine (1 μg/kg/min, IV) was administered during the last 15 minutes of anesthesia before euthanasia. The primary outcome cardiac index (CI; saline thermodilution technique) was recorded at baseline, 1 hour after oral dosing, after sedation and induction, and every 15 minutes under anesthesia. Data were compared between groups using a mixed model.
Results: All 12 horses completed the study. No significant differences were observed between groups at all time points except after dobutamine infusion, where CI (mean ± SD) was significantly higher in the trazodone group (66.2 ± 16.8 mL/min/kg) than the control group (46.8 ± 6.6 mL/min/kg). One horse in the trazodone group displayed signs of colic after dosing, with markedly reduced CI during anesthesia compared to all other horses.
Conclusions: Oral trazodone before isoflurane anesthesia in healthy horses produced variable cardiovascular function, including profound cardiovascular depression in 1 horse.
Clinical relevance: Profound individual cardiovascular responses may be seen with routine preanesthetic trazodone in horses.
期刊介绍：
The American Journal of Veterinary Research supports the collaborative exchange of information between researchers and clinicians by publishing novel research findings that bridge the gulf between basic research and clinical practice or that help to translate laboratory research and preclinical studies to the development of clinical trials and clinical practice. The journal welcomes submission of high-quality original studies and review articles in a wide range of scientific fields, including anatomy, anesthesiology, animal welfare, behavior, epidemiology, genetics, heredity, infectious disease, molecular biology, oncology, pharmacology, pathogenic mechanisms, physiology, surgery, theriogenology, toxicology, and vaccinology. Species of interest include production animals, companion animals, equids, exotic animals, birds, reptiles, and wild and marine animals. Reports of laboratory animal studies and studies involving the use of animals as experimental models of human diseases are considered only when the study results are of demonstrable benefit to the species used in the research or to another species of veterinary interest. Other fields of interest or animals species are not necessarily excluded from consideration, but such reports must focus on novel research findings. Submitted papers must make an original and substantial contribution to the veterinary medicine knowledge base; preliminary studies are not appropriate.
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