Structural and functional capillary integrity, arterial stiffness and central hemodynamics in CKD patients with and without nocturnal hypertension.

Abstract

Background: Nocturnal hypertension is associated with increased risk for renal and cardiovascular events in patients with chronic-kidney-disease(CKD). Endothelial dysfunction and microvascular damage are highly prevalent in CKD and related to CKD progression and adverse cardiovascular outcomes. The aim of this analysis was to compare for first time microcirculatory function parameters and central hemodynamics in CKD patients with and without nocturnal hypertension.

Methods: 96 pre-dialysis CKD patients underwent 24-h ABPM (Mobil-O-Graph-NG device) and nailfold video-capillaroscopy, during which capillary density was measured at baseline, after 4-min arterial occlusion (postocclusive-reactive-hyperemia) and following 2-min venous occlusion (congestion phase). Arterial stiffness and central hemodynamic were captured in office conditions with Sphygmocor.

Results: The two groups (with and without nocturnal hypertension) were similar in terms of age, eGFR, BMI and major comorbidities. Patients with nocturnal hypertension presented significantly lower capillary density at baseline (30.6±3.6 vs 33.1±3.2 capillaries/mm2; p=0.003), during post-occlusive reactive hyperemia (36.6±4 vs. 39.5±3.9 capillaries/mm2; p=0.003), and during venous congestion (38.1±4.2 vs. 41±3.5 capillaries/mm2; p=0.003) compared to those without nocturnal hypertension. Participants with nocturnal hypertension had significantly higher aortic BP; no differences were found in the other parameters of arterial stiffness. The above observations were more prominent in patients with diabetes.

Conclusions: Capillary density during postocclusive hyperemia and after venous congestion is lower in patients with nocturnal hypertension compared to those with normotension, suggesting that nocturnal hypertension is a factor superimposed on the microvascular changes characterizing CKD to further impair capillary recruitment.