Clinical, Epidemiological, Virological Characteristics and Outcomes of 286 Patients Infected With Monkeypox Virus in China.

IF 12.6 1区 医学 Q1 ALLERGY
Allergy Pub Date : 2025-03-29 DOI:10.1111/all.16540
Hankun Hu, Yang Zheng, Lianguo Ruan, Yamin Liu, Yeqing Tong, Yaokai Chen, Ke Liang, Li Zhou, Wu Chen, Yixin Hu, Wei Song, Feng Lv, Yaodong Ping, Kaiwen Fang, Nan Zhang, Hongxia Wei, Cezmi A Akdis, Ping Ma, Yadong Gao
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引用次数: 0

Abstract

Background: Monkeypox virus (mpox) outbreak since 2022 has already constituted a public health emergency of international concern. A comprehensive study on epidemiological features, symptoms and signs, complications, sequelae, and clinical outcomes has been lacking. Accordingly, we performed a large-scale multicenter study to comprehensively summarize the clinical, epidemiological, behavioral, laboratory, virological characteristics, and treatment-related outcomes of mpox in China.

Method: In this multicenter hospital-based retrospective study, demographic information, clinical characteristics, laboratory results, hospitalization records, prescribed medications, and clinical outcomes were extracted from the electronic medical records of 286 confirmed mpox cases from five regions of China.

Result: An approximately 1:1 ratio of HIV-positive (52.1%) and HIV-negative was found, with an overall median age of 32 years (IQR 27-37). Most patients were male (99.3%), lived in urban areas (86.0%), single (72.6%), and had a college degree or higher (62.0%). Men having sex with men (MSM) was the predominant sexual orientation (83.0%), and sexual contact was the most likely mode of exposure (85.4%). 17 (9.6%) patients reported a history of smallpox vaccination. Hundered and seven patients had at least one co-morbid other sexually transmitted infection. Fourteen patients had a self-reported history of allergy. Significant differences were found between HIV-negative and HIV-positive mpox in the proportion of MSM, anal and perianal pain, levels of AST, CRP, CD4+ T-cell, CD8+ T-cell, NK-cell levels, and clinical outcomes.

Conclusion: MSM individuals with an interquartile age range of 27-37 years, particularly from coastal or developed regions of China, were identified as "main affected population" for mpox prevention and control. HIV infection may contribute to more severe mpox manifestations, characterized by elevated AST and CRP levels, reduced CD4 + T-cell and NK-cell counts, and unfavorable clinical outcomes with increased mortality.

286例猴痘病毒感染的临床、流行病学、病毒学特征及转归
背景:自2022年以来猴痘病毒(mpox)暴发已构成国际关注的突发公共卫生事件。对该病的流行病学特征、症状和体征、并发症、后遗症和临床结果缺乏全面的研究。因此,我们进行了一项大规模的多中心研究,以全面总结中国麻疹的临床、流行病学、行为、实验室、病毒学特征和治疗相关结果。方法:采用多中心医院为基础的回顾性研究方法,从中国5个地区286例确诊mpox病例的电子病历中提取人口学信息、临床特征、实验室结果、住院记录、处方用药和临床结果。结果:hiv阳性与hiv阴性比例约为1:1(52.1%),总体中位年龄32岁(IQR 27 ~ 37)。大多数患者为男性(99.3%),居住在城市(86.0%),单身(72.6%),大专及以上学历(62.0%)。男男性行为(MSM)是主要的性取向(83.0%),性接触是最常见的暴露方式(85.4%)。17例(9.6%)患者报告有天花疫苗接种史。107名患者至少同时患有一种其他性传播感染。14名患者有自我报告的过敏史。hiv阴性和hiv阳性mpox患者在MSM比例、肛门和肛周疼痛、AST、CRP水平、CD4+ t细胞、CD8+ t细胞、nk细胞水平和临床转归方面存在显著差异。结论:四分位数年龄范围为27 ~ 37岁的MSM人群,特别是沿海和发达地区的MSM人群是m痘防控的“主要影响人群”。HIV感染可能导致更严重的m痘表现,其特征是AST和CRP水平升高,CD4 + t细胞和nk细胞计数降低,以及不利的临床结果,死亡率增加。
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来源期刊
Allergy
Allergy 医学-过敏
CiteScore
26.10
自引率
9.70%
发文量
393
审稿时长
2 months
期刊介绍: Allergy is an international and multidisciplinary journal that aims to advance, impact, and communicate all aspects of the discipline of Allergy/Immunology. It publishes original articles, reviews, position papers, guidelines, editorials, news and commentaries, letters to the editors, and correspondences. The journal accepts articles based on their scientific merit and quality. Allergy seeks to maintain contact between basic and clinical Allergy/Immunology and encourages contributions from contributors and readers from all countries. In addition to its publication, Allergy also provides abstracting and indexing information. Some of the databases that include Allergy abstracts are Abstracts on Hygiene & Communicable Disease, Academic Search Alumni Edition, AgBiotech News & Information, AGRICOLA Database, Biological Abstracts, PubMed Dietary Supplement Subset, and Global Health, among others.
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