Association of Age With Glaucoma and Visual Acuity Outcomes 10.5 Years After Unilateral Congenital Cataract Surgery

IF 4.1 1区医学 Q1 OPHTHALMOLOGY

American Journal of Ophthalmology Pub Date : 2025-03-26 DOI:10.1016/j.ajo.2025.03.035

Claudia K. Wong , He Forbes , Taylor Kolosky , Urjita Das , Euna Cho , Shaiza Mansoor , Sera Chase , Madi Kore , Moran Roni Levin , Larry Magder , Carolyn Drews-Botsch , Scott R. Lambert , Janet L. Alexander

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引用次数: 0

Abstract

OBJECTIVE

To determine the association among age, gestational age, glaucoma-related adverse events, and visual acuity following unilateral cataract surgery.

DESIGN

Post hoc follow-up of a multicenter randomized clinical trial.

METHODS

An analysis of 112 infants who had unilateral congenital cataract surgery between 1-6 months of chronological age. Data on long-term glaucoma-related status and visual acuity were collected when children were 10.5 years old. Intergroup comparison and correlation tests were performed, and associations of adjusted and chronological age with glaucoma and visual acuity at 10.5 years of age were assessed by logistic regression.

RESULTS

Chronological and adjusted age were highly correlated (Pearson correlation, r = 0.98, P < .001). Gestational age was not significantly associated with glaucoma (P = .08) nor visual acuity (P = .6). Younger adjusted age had a significant association with glaucoma (P = .04) and with better visual acuity (P = .03). Younger chronological age was not significantly associated with glaucoma (P = .06) but had a significant association with better visual acuity (P = .02).

CONCLUSIONS

Age adjusted for gestation and chronological age are important risk factors for glaucoma and visual acuity in patients who have undergone cataract removal in infancy. Among the IATS participants, age adjusted for gestation significantly predicted glaucoma-related adverse events at 10.5 years. Conversely, chronological age was significantly associated with visual acuity at 10.5 years. Adjusted age should be considered in addition to chronological age when determining age of cataract surgery to minimize the risk of glaucoma and maximize visual acuity.

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来源期刊

American Journal of Ophthalmology 医学-眼科学

CiteScore

9.20

自引率

7.10%

发文量

406

审稿时长

36 days

期刊介绍： The American Journal of Ophthalmology is a peer-reviewed, scientific publication that welcomes the submission of original, previously unpublished manuscripts directed to ophthalmologists and visual science specialists describing clinical investigations, clinical observations, and clinically relevant laboratory investigations. Published monthly since 1884, the full text of the American Journal of Ophthalmology and supplementary material are also presented online at www.AJO.com and on ScienceDirect. The American Journal of Ophthalmology publishes Full-Length Articles, Perspectives, Editorials, Correspondences, Books Reports and Announcements. Brief Reports and Case Reports are no longer published. We recommend submitting Brief Reports and Case Reports to our companion publication, the American Journal of Ophthalmology Case Reports. Manuscripts are accepted with the understanding that they have not been and will not be published elsewhere substantially in any format, and that there are no ethical problems with the content or data collection. Authors may be requested to produce the data upon which the manuscript is based and to answer expeditiously any questions about the manuscript or its authors.