The Complex Interplay of Irisin Levels, Low Birth Weight, and Blood Pressure in Prepubescent Children

IF 1.6 4区医学 Q1 ANTHROPOLOGY

American Journal of Human Biology Pub Date : 2025-03-31 DOI:10.1002/ajhb.70036

Raissa Munhão Serra, Franciele De Meneck, Fernanda Thomazini, Paula Regina Pereira de Souza, Maria Franco

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引用次数: 0

Abstract

Background

Irisin regulates various metabolic, inflammatory, and oxidative stress processes. It has been considered a promising target in the context of the development and maintenance of cardiovascular diseases. We conducted a study to evaluate the levels of plasma irisin in prepubertal children, examining its relationship with birth weight, anthropometric parameters, biochemical profile, and blood pressure levels.

Methods

A cross-sectional study was conducted involving 136 prepubertal children aged 6 to 11 years, with 27.9% born at a low weight. Anthropometric parameters, blood pressure, and biochemical profiles were assessed.

Results

Children with low birth weight had significantly lower irisin levels compared to those with normal birth weight (p < 0.001). Birth weight was negatively correlated with blood pressure levels (systolic: r = −0.213, p = 0.013; diastolic: r = −0.223, p = 0.009) and positively correlated with irisin levels (p < 0.001). Irisin levels were positively associated with systolic blood pressure, even after adjusting for birth weight, BMI, and physical activity (p < 0.001). The linear regression analysis indicated that low birth weight and high plasma levels of irisin were recognized as predictive factors of elevated blood pressure levels.

Conclusion

The positive correlation observed between circulating irisin and systolic blood pressure levels in children with low birth weight, despite their lower irisin levels, suggests a complex interplay between birth weight, irisin, cardiovascular regulation, and metabolic function. Understanding this relationship may require considering that irisin may play dual roles in different tissues, compensatory mechanisms, and the broader context of cardiometabolic programming in children with low birth weight.

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青春期前儿童鸢尾素水平、低出生体重和血压的复杂相互作用

鸢尾素调节各种代谢、炎症和氧化应激过程。在心血管疾病发展和维持的背景下，它被认为是一个有希望的目标。我们进行了一项研究，评估青春期前儿童血浆中鸢尾素的水平，研究其与出生体重、人体测量参数、生化特征和血压水平的关系。方法对136例6 ~ 11岁的青春期前儿童进行横断面研究，其中27.9%为低体重儿。评估人体测量参数、血压和生化特征。结果低出生体重儿的鸢尾素水平明显低于正常出生体重儿（p < 0.001）。出生体重与血压水平呈负相关(收缩压：r = - 0.213, p = 0.013；舒张：r = - 0.223, p = 0.009)，与鸢尾素水平正相关（p < 0.001）。鸢尾素水平与收缩压呈正相关，即使在调整出生体重、BMI和身体活动后也是如此（p < 0.001）。线性回归分析表明，低出生体重和高血浆鸢尾素水平被认为是血压升高的预测因素。结论低出生体重儿童的循环鸢尾素与收缩压水平呈正相关，尽管他们的鸢尾素水平较低，但这表明出生体重、鸢尾素、心血管调节和代谢功能之间存在复杂的相互作用。理解这种关系可能需要考虑鸢尾素可能在不同的组织、代偿机制和低出生体重儿童心脏代谢程序的更广泛背景中发挥双重作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

American Journal of Human Biology 生物-生物学

CiteScore

4.80

自引率

13.80%

发文量

124

审稿时长

4-8 weeks

期刊介绍： The American Journal of Human Biology is the Official Journal of the Human Biology Association. The American Journal of Human Biology is a bimonthly, peer-reviewed, internationally circulated journal that publishes reports of original research, theoretical articles and timely reviews, and brief communications in the interdisciplinary field of human biology. As the official journal of the Human Biology Association, the Journal also publishes abstracts of research presented at its annual scientific meeting and book reviews relevant to the field. The Journal seeks scholarly manuscripts that address all aspects of human biology, health, and disease, particularly those that stress comparative, developmental, ecological, or evolutionary perspectives. The transdisciplinary areas covered in the Journal include, but are not limited to, epidemiology, genetic variation, population biology and demography, physiology, anatomy, nutrition, growth and aging, physical performance, physical activity and fitness, ecology, and evolution, along with their interactions. The Journal publishes basic, applied, and methodologically oriented research from all areas, including measurement, analytical techniques and strategies, and computer applications in human biology. Like many other biologically oriented disciplines, the field of human biology has undergone considerable growth and diversification in recent years, and the expansion of the aims and scope of the Journal is a reflection of this growth and membership diversification. The Journal is committed to prompt review, and priority publication is given to manuscripts with novel or timely findings, and to manuscripts of unusual interest.