The Complex Interplay of Irisin Levels, Low Birth Weight, and Blood Pressure in Prepubescent Children

IF 1.6 4区 医学 Q1 ANTHROPOLOGY
Raissa Munhão Serra, Franciele De Meneck, Fernanda Thomazini, Paula Regina Pereira de Souza, Maria Franco
{"title":"The Complex Interplay of Irisin Levels, Low Birth Weight, and Blood Pressure in Prepubescent Children","authors":"Raissa Munhão Serra,&nbsp;Franciele De Meneck,&nbsp;Fernanda Thomazini,&nbsp;Paula Regina Pereira de Souza,&nbsp;Maria Franco","doi":"10.1002/ajhb.70036","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Background</h3>\n \n <p>Irisin regulates various metabolic, inflammatory, and oxidative stress processes. It has been considered a promising target in the context of the development and maintenance of cardiovascular diseases. We conducted a study to evaluate the levels of plasma irisin in prepubertal children, examining its relationship with birth weight, anthropometric parameters, biochemical profile, and blood pressure levels.</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>A cross-sectional study was conducted involving 136 prepubertal children aged 6 to 11 years, with 27.9% born at a low weight. Anthropometric parameters, blood pressure, and biochemical profiles were assessed.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>Children with low birth weight had significantly lower irisin levels compared to those with normal birth weight (<i>p</i> &lt; 0.001). Birth weight was negatively correlated with blood pressure levels (systolic: <i>r</i> = −0.213, <i>p =</i> 0.013; diastolic: <i>r</i> = −0.223, <i>p =</i> 0.009) and positively correlated with irisin levels (<i>p</i> &lt; 0.001). Irisin levels were positively associated with systolic blood pressure, even after adjusting for birth weight, BMI, and physical activity (<i>p</i> &lt; 0.001). The linear regression analysis indicated that low birth weight and high plasma levels of irisin were recognized as predictive factors of elevated blood pressure levels.</p>\n </section>\n \n <section>\n \n <h3> Conclusion</h3>\n \n <p>The positive correlation observed between circulating irisin and systolic blood pressure levels in children with low birth weight, despite their lower irisin levels, suggests a complex interplay between birth weight, irisin, cardiovascular regulation, and metabolic function. Understanding this relationship may require considering that irisin may play dual roles in different tissues, compensatory mechanisms, and the broader context of cardiometabolic programming in children with low birth weight.</p>\n </section>\n </div>","PeriodicalId":50809,"journal":{"name":"American Journal of Human Biology","volume":"37 4","pages":""},"PeriodicalIF":1.6000,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"American Journal of Human Biology","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/ajhb.70036","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ANTHROPOLOGY","Score":null,"Total":0}
引用次数: 0

Abstract

Background

Irisin regulates various metabolic, inflammatory, and oxidative stress processes. It has been considered a promising target in the context of the development and maintenance of cardiovascular diseases. We conducted a study to evaluate the levels of plasma irisin in prepubertal children, examining its relationship with birth weight, anthropometric parameters, biochemical profile, and blood pressure levels.

Methods

A cross-sectional study was conducted involving 136 prepubertal children aged 6 to 11 years, with 27.9% born at a low weight. Anthropometric parameters, blood pressure, and biochemical profiles were assessed.

Results

Children with low birth weight had significantly lower irisin levels compared to those with normal birth weight (p < 0.001). Birth weight was negatively correlated with blood pressure levels (systolic: r = −0.213, p = 0.013; diastolic: r = −0.223, p = 0.009) and positively correlated with irisin levels (p < 0.001). Irisin levels were positively associated with systolic blood pressure, even after adjusting for birth weight, BMI, and physical activity (p < 0.001). The linear regression analysis indicated that low birth weight and high plasma levels of irisin were recognized as predictive factors of elevated blood pressure levels.

Conclusion

The positive correlation observed between circulating irisin and systolic blood pressure levels in children with low birth weight, despite their lower irisin levels, suggests a complex interplay between birth weight, irisin, cardiovascular regulation, and metabolic function. Understanding this relationship may require considering that irisin may play dual roles in different tissues, compensatory mechanisms, and the broader context of cardiometabolic programming in children with low birth weight.

求助全文
约1分钟内获得全文 求助全文
来源期刊
CiteScore
4.80
自引率
13.80%
发文量
124
审稿时长
4-8 weeks
期刊介绍: The American Journal of Human Biology is the Official Journal of the Human Biology Association. The American Journal of Human Biology is a bimonthly, peer-reviewed, internationally circulated journal that publishes reports of original research, theoretical articles and timely reviews, and brief communications in the interdisciplinary field of human biology. As the official journal of the Human Biology Association, the Journal also publishes abstracts of research presented at its annual scientific meeting and book reviews relevant to the field. The Journal seeks scholarly manuscripts that address all aspects of human biology, health, and disease, particularly those that stress comparative, developmental, ecological, or evolutionary perspectives. The transdisciplinary areas covered in the Journal include, but are not limited to, epidemiology, genetic variation, population biology and demography, physiology, anatomy, nutrition, growth and aging, physical performance, physical activity and fitness, ecology, and evolution, along with their interactions. The Journal publishes basic, applied, and methodologically oriented research from all areas, including measurement, analytical techniques and strategies, and computer applications in human biology. Like many other biologically oriented disciplines, the field of human biology has undergone considerable growth and diversification in recent years, and the expansion of the aims and scope of the Journal is a reflection of this growth and membership diversification. The Journal is committed to prompt review, and priority publication is given to manuscripts with novel or timely findings, and to manuscripts of unusual interest.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信