Low Intrahepatic Distant Recurrence Rate Following RFA Using Linear Mode in Patients With Hepatocellular Carcinoma

IF 1.7 Q3 GASTROENTEROLOGY & HEPATOLOGY

JGH Open Pub Date : 2025-04-01 DOI:10.1002/jgh3.70145

Hiroaki Takaya, Tadashi Namisaki, Yusuke Komeda, Hiroki Kinoshita, Naoki Nishimura, Yuki Tsuji, Shinya Sato, Norihisa Nishimura, Ko Saito, Shigeyuki Aizawa, Chie Morioka, Ryuichi Noguchi, Motoyuki Yoshida, Kosuke Kaji, Hitoshi Yoshiji

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Abstract

Background

Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide. Radiofrequency ablation (RFA) can be utilized in elderly patients and those with cirrhosis with reduced functional liver reserve as it is less invasive. The arfa RFA system is the first system to offer a linear mode. However, the differences in performance between the linear and existing (nonlinear) modes remain unknown.

Aim

This retrospective observational study compared the performance of the linear (linear group) and nonlinear RFA modes (nonlinear group) in HCC.

Methods

Data of 425 patients with one to three HCC tumors measuring ≤ 3 cm who underwent RFA were analyzed. Recurrence (local and distant), survival, and complication rates between the linear and nonlinear groups were determined.

Results

The intrahepatic distant recurrence rate was lower in the linear group than in the nonlinear group (p < 0.05). Multivariate analysis showed that the high platelet count, low AFP-L3 levels, initial case, and linear mode were independent factors associated with a low intrahepatic distant recurrence rate following RFA. Liver disease-related survival, HCC survival, overall survival of the initial HCC, local recurrence, and complication rates were comparable between the linear and nonlinear groups.

Conclusion

The linear mode of the RFA protocol results in a lower intrahepatic distant recurrence rate compared with the nonlinear protocol.

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肝细胞癌患者行线性RFA术后肝内远端复发率低

肝细胞癌（HCC）是世界范围内最常见的癌症之一。射频消融术（RFA）可用于老年患者和肝功能储备减少的肝硬化患者，因为它的侵入性较小。arfa RFA系统是第一个提供线性模式的系统。然而，线性和现有（非线性）模式之间的性能差异仍然未知。目的：本回顾性观察研究比较线性RFA（线性组）和非线性RFA（非线性组）治疗HCC的疗效。方法对425例1 ~ 3个≤3cm HCC患者行RFA的资料进行分析。确定线性组和非线性组的复发率（局部和远处）、生存率和并发症发生率。结果线性组肝内远端复发率低于非线性组（p < 0.05）。多因素分析显示，血小板计数高、AFP-L3水平低、初始病例和线性模式是RFA术后肝内远端复发率低的独立因素。肝脏疾病相关生存率、HCC生存率、原发性HCC总生存率、局部复发率和并发症发生率在线性组和非线性组之间具有可比性。结论与非线性方案相比，线性RFA方案可降低肝内远端复发率。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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