IgG In Saliva, GCF, and Serum in Young Patients With Grade C Molar Incisor Pattern Periodontitis

IF 1.7 Q3 DENTISTRY, ORAL SURGERY & MEDICINE

Clinical and Experimental Dental Research Pub Date : 2025-03-30 DOI:10.1002/cre2.70117

Meaad M. Alamri, Gordon Proctor, Luigi Nibali

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引用次数: 0

Abstract

Objective

This cross-sectional study aimed to investigate immunoglobulin G levels in saliva, gingival crevicular fluid, and serum samples from young patients with grade C molar incisor pattern periodontitis (C/MIP) and age-matched periodontitis-free controls.

Methods

Saliva, gingival crevicular fluid, and blood samples were collected from 62 patients, divided into 31 cases and 31 periodontitis-free age-matched controls. Saliva and blood samples were centrifuged to extract supernatant and serum. Gingival crevicular fluid periopapers were eluted. Human total immunoglobulin G levels were assessed using an Enzyme-Linked Immunosorbent Assay.

Results

After adjusting for covariates, cases had higher Immunoglobulin G levels in saliva (p = 0.005), gingival crevicular fluid (p < 0.001) than controls; however, serum did not reach the significant threshold (p = 0.137). Among other factors contributing to immunoglobulin G levels, males had higher serum immunoglobulin G than females (p = 0.018), and serum immunoglobulin G levels increased with age (p = 0.033). Gender and ethnicity subgroup analyses revealed that C/MIP males had higher saliva IgG (p = 0.018) than control males, and both genders had higher GCF IgG than controls (p ≤ 0.001). C/MIP Caucasians had elevated saliva (p = 0.011) and GCF IgG p = (0.003) compared to the controls, and Asians had higher GCF IgG than the controls (p = 0.011).

Conclusion

This study shows for the first time that C/MIP cases have higher Immunoglobulin G levels than controls in saliva and gingival crevicular fluid, confirming its association with C/MIP pathogenesis and suggesting that it could be a potential biomarker in grade C molar incisor pattern periodontitis. Further research on a larger sample size is needed.

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青年C级磨牙型牙周炎患者唾液、GCF和血清中IgG的含量

目的本研究旨在探讨C级磨牙型牙周炎（C/MIP）患者和年龄匹配的无牙周炎对照者唾液、龈沟液和血清中的免疫球蛋白G水平。方法对62例牙周炎患者进行唾液、龈沟液和血液采集，分为31例牙周炎患者和31例无牙周炎年龄匹配的对照组。唾液和血样离心提取上清和血清。冲洗龈沟液周膜。使用酶联免疫吸附试验评估人总免疫球蛋白G水平。结果经协变量调整后，患者唾液（p = 0.005）、龈沟液（p < 0.001）免疫球蛋白G水平均高于对照组；血清未达到显著阈值（p = 0.137）。在影响免疫球蛋白G水平的其他因素中，男性血清免疫球蛋白G高于女性（p = 0.018），血清免疫球蛋白G水平随着年龄的增长而增加（p = 0.033）。性别和种族亚组分析显示，C/MIP男性的唾液IgG高于对照组（p = 0.018），两种性别的GCF IgG均高于对照组（p≤0.001）。与对照组相比，C/MIP白种人唾液和GCF IgG升高（p = 0.011），而亚洲人GCF IgG高于对照组（p = 0.011）。结论本研究首次发现C/MIP患者唾液和龈沟液中免疫球蛋白G水平高于对照组，证实了其与C/MIP发病机制的关联，提示其可能是C级磨牙型牙周炎的潜在生物标志物。需要对更大的样本量进行进一步研究。

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来源期刊

Clinical and Experimental Dental Research DENTISTRY, ORAL SURGERY & MEDICINE-

CiteScore

3.30

自引率

5.60%

发文量

165

审稿时长

26 weeks

期刊介绍： Clinical and Experimental Dental Research aims to provide open access peer-reviewed publications of high scientific quality representing original clinical, diagnostic or experimental work within all disciplines and fields of oral medicine and dentistry. The scope of Clinical and Experimental Dental Research comprises original research material on the anatomy, physiology and pathology of oro-facial, oro-pharyngeal and maxillofacial tissues, and functions and dysfunctions within the stomatognathic system, and the epidemiology, aetiology, prevention, diagnosis, prognosis and therapy of diseases and conditions that have an effect on the homeostasis of the mouth, jaws, and closely associated structures, as well as the healing and regeneration and the clinical aspects of replacement of hard and soft tissues with biomaterials, and the rehabilitation of stomatognathic functions. Studies that bring new knowledge on how to advance health on the individual or public health levels, including interactions between oral and general health and ill-health are welcome.