Diacerein's Role in Alleviating Inflammation and Synovial Effusion in Knee Osteoarthritis: A Novel Therapeutic Approach

Saim Mahmood Khan, Marium Amjad, Rida Shakil, Eisha Shoaib, Dong Hwi Kim, Jawairya Muhammad Hussain
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Abstract

Diacerein, an anthraquinone derivative, has gained interest in recent years as a potential therapeutic agent in the management of knee osteoarthritis (KOA), particularly the inflammatory subtype effusion synovitis. This commentary evaluates the effect of diacerein on KOA symptoms and functional outcomes of recent parts of a multicenter randomized controlled trial. The clinical trial of diacerein as a monotherapy for effusion synovitis concluded that not only was there no overall significant change in the knee joint's moisture content after a 24-week therapy but also there was no evidence of symptomatic or functional improvement. Furthermore, problems like diarrhea and colored urine raised questions about its safety and user-friendly profile; therefore, these findings were contentious. These outcomes highlight the need for greater investigation of diacerein, including in combination therapies where its benefits are amplified and adverse effects diminished. Further research should help to define diacerein's role in KOA treatment and increase the understanding of its actions regarding effusion synovitis, focusing on side effects.

Abstract Image

双醋瑞因是一种蒽醌衍生物,近年来作为治疗膝骨关节炎(KOA),尤其是炎症亚型渗出性滑膜炎的潜在治疗药物而备受关注。这篇评论评估了 diacerein 对 KOA 症状的影响以及多中心随机对照试验近期部分的功能结果。迪卡瑞林作为单一疗法治疗渗出性滑膜炎的临床试验结果表明,经过 24 周的治疗后,膝关节的含水量不仅没有整体上的显著变化,而且也没有症状或功能改善的证据。此外,腹泻和有色尿液等问题也对其安全性和用户友好性提出了质疑;因此,这些研究结果是有争议的。这些结果突出表明,有必要对泻肝素进行更深入的研究,包括在联合疗法中,因为在联合疗法中,泻肝素的益处会更大,而不良反应会更小。进一步的研究应有助于确定迪卡瑞林在 KOA 治疗中的作用,并加深人们对其在渗出性滑膜炎方面作用的了解,重点关注其副作用。
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