Facile fabrication of CdS@GO binary nanocomposite coated GCE for separate and parallel electrochemical sensing of ascorbic acid, uric acid and nitrite

IF 5.5 3区材料科学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Carbon Letters Pub Date : 2025-01-23 DOI:10.1007/s42823-024-00838-7

A. Dhamodharan, E. Murugan, Huan Pang, K. Perumal, K. Jhansirani, Yajun Gao

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引用次数: 0

Abstract

The accurate detection of vital biomarkers such as Ascorbic Acid (AA), Uric Acid (UA) and Nitrite (NO₂⁻) is crucial for human health surveillance. However, existing methods often struggle with concurrent detection and quantification of multiple species, highlighting the need for a more effective solution. To address this challenge, this study aimed to develop a multifunctional electrochemical sensor capable of parallel detection of AA, UA and NO₂⁻ using a synergistic combination of Graphene Oxide (GO) and Cadmium Sulfide (CdS) materials. Notably, the fabricated CdS@GO/Glassy Carbon Electrode (GCE) exhibited exceptional electrochemical activity, as evidenced by Differential Pulse Voltammetry (DPV) analysis. The sensor demonstrated remarkable sensitivity (8.13, 10.12, and 9.05 μA·μM⁻¹·cm⁻²) and ultra-low detection limits (0.034, 0.062, and 0.084 µM) for AA, UA and NO₂⁻, respectively. Furthermore, it successfully identified single molecules of each analyte in aqueous and biologic fluid samples, with recovery values comparable to those obtained using High-Performance Liquid Chromatography (HPLC) standard addition methods. The significance of this study lies in developing a novel CdS@GO/GCE sensor that enables concurrent detection and quantification of multiple vital biomarkers, offering a promising tool for human health monitoring and diagnosis.

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用于抗坏血酸、尿酸和亚硝酸盐分离和并行电化学传感的CdS@GO二元纳米复合涂层GCE的制备

准确检测抗坏血酸（AA）、尿酸（UA）和亚硝酸盐（NO2-）等重要生物标志物对于人类健康监测至关重要。然而，现有的方法往往难以同时检测和量化多个物种，因此需要一种更有效的解决方案。为了应对这一挑战，本研究旨在利用石墨烯氧化物（GO）和硫化镉（CdS）材料的协同组合，开发一种能够同时检测 AA、UA 和 NO2- 的多功能电化学传感器。值得注意的是，制备的 CdS@GO/Glassy Carbon Electrode (GCE) 具有优异的电化学活性，这一点已在差分脉冲伏安法 (DPV) 分析中得到证实。该传感器对 AA、UA 和 NO2- 分别表现出极高的灵敏度（8.13、10.12 和 9.05 μA-μM-1-cm-2）和超低的检测限（0.034、0.062 和 0.084 µM）。此外，它还成功地鉴定了水和生物液体样品中每种分析物的单分子，其回收率与使用高效液相色谱（HPLC）标准添加方法获得的回收率相当。这项研究的意义在于开发了一种新型 CdS@GO/GCE 传感器，可同时检测和量化多种重要的生物标志物，为人类健康监测和诊断提供了一种前景广阔的工具。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Carbon Letters CHEMISTRY, MULTIDISCIPLINARY-MATERIALS SCIENCE, MULTIDISCIPLINARY

CiteScore

7.30

自引率

20.00%

发文量

118

期刊介绍： Carbon Letters aims to be a comprehensive journal with complete coverage of carbon materials and carbon-rich molecules. These materials range from, but are not limited to, diamond and graphite through chars, semicokes, mesophase substances, carbon fibers, carbon nanotubes, graphenes, carbon blacks, activated carbons, pyrolytic carbons, glass-like carbons, etc. Papers on the secondary production of new carbon and composite materials from the above mentioned various carbons are within the scope of the journal. Papers on organic substances, including coals, will be considered only if the research has close relation to the resulting carbon materials. Carbon Letters also seeks to keep abreast of new developments in their specialist fields and to unite in finding alternative energy solutions to current issues such as the greenhouse effect and the depletion of the ozone layer. The renewable energy basics, energy storage and conversion, solar energy, wind energy, water energy, nuclear energy, biomass energy, hydrogen production technology, and other clean energy technologies are also within the scope of the journal. Carbon Letters invites original reports of fundamental research in all branches of the theory and practice of carbon science and technology.