Magnetically induced heating efficiency of viscoelastic Ni substituted MnFe2O4 magnetic nanofluids for hyperthermia application

IF 4.9 2区化学 Q2 CHEMISTRY, PHYSICAL

Colloids and Surfaces A: Physicochemical and Engineering Aspects Pub Date : 2025-03-24 DOI:10.1016/j.colsurfa.2025.136747

Mohd Aamir Khan , G.A. Basheed , Kuldeep , Megha Singh , Surya Prakash Singh

{"title":"Magnetically induced heating efficiency of viscoelastic Ni substituted MnFe2O4 magnetic nanofluids for hyperthermia application","authors":"Mohd Aamir Khan , G.A. Basheed , Kuldeep , Megha Singh , Surya Prakash Singh","doi":"10.1016/j.colsurfa.2025.136747","DOIUrl":null,"url":null,"abstract":"<div><div>In the pursuit of finding an optimal heat dissipator aqueous magnetic nanofluid (MNFs) for hyperthermia treatment, PEG-400 coated NiₓMn1-xFe₂O₄ (0 ≤ x ≤ 0.8) magnetic nanoparticles (MNPs) were synthesized using a novel sonication-assisted reverse chemical co-precipitation method. The Rietveld refined X-ray diffraction pattern of NiₓMn1-xFe₂O₄ MNPs ensures the single phase with crystallite size varies from 28 to 40 nm. X-ray photoelectron spectroscopy (XPS) analysis further revealed the surface composition and oxidation states of Ni²⁺, Fe³ ⁺, and Mn²⁺ ions. The colloidal stability was demonstrated by the increased zeta potential (ζ), ranging from −59 to −22 mV, indicating stronger electrostatic repulsion between the NiₓMn1-xFe₂O₄ MNPs. The substitution of Ni2 + ions reduces the magnetic moment, as evidenced by a decrease in saturation magnetization and an increase in coercive field. This reduction is further supported by dynamic magnetization measurements, which exhibit an increase in resonance field and a narrower peak-to-peak linewidth. These changes are attributed to the replacement of Mn²⁺ ions by Ni²⁺ ions, which suppresses the superexchange interaction between Mn²⁺-O-Fe³ ⁺ ions. Furthermore, the self-heating efficiency was evaluated through a specific absorption rate (SAR) under an alternating magnetic field of 9.5 kA/m. Among NiₓMn1-xFe₂O₄ MNFs, the MnFe2O4 achieves the highest SAR of 129 W/g at a low concentration of 1 mg/mL. Additionally, the calculated Intrinsic Loss Power (ILP) value of NixMn1-xFe2O4 MNFs (2.417–0.277 nHm2kg−1) is comparable to those of medically approved magnetic fluids (3.1–0.15 nHm2kg−1) used in hyperthermia treatments. Consequently, the synthesized NiₓMn1-xFe₂O₄ MNPs demonstrate the potential for effective cancer treatment at low concentrations (1 mg/mL) and low magnetic fields (9.5 kA/m). The results demonstrated that NiₓMn1-xFe2O4 MNPs generated localized heating suitable for hyperthermic cancer treatments.</div></div>","PeriodicalId":278,"journal":{"name":"Colloids and Surfaces A: Physicochemical and Engineering Aspects","volume":"717 ","pages":"Article 136747"},"PeriodicalIF":4.9000,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Colloids and Surfaces A: Physicochemical and Engineering Aspects","FirstCategoryId":"92","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0927775725006508","RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, PHYSICAL","Score":null,"Total":0}

引用次数: 0

Abstract

In the pursuit of finding an optimal heat dissipator aqueous magnetic nanofluid (MNFs) for hyperthermia treatment, PEG-400 coated NiₓMn_1-xFe₂O₄ (0 ≤ x ≤ 0.8) magnetic nanoparticles (MNPs) were synthesized using a novel sonication-assisted reverse chemical co-precipitation method. The Rietveld refined X-ray diffraction pattern of NiₓMn_1-xFe₂O₄ MNPs ensures the single phase with crystallite size varies from 28 to 40 nm. X-ray photoelectron spectroscopy (XPS) analysis further revealed the surface composition and oxidation states of Ni²⁺, Fe³ ⁺, and Mn²⁺ ions. The colloidal stability was demonstrated by the increased zeta potential (ζ), ranging from −59 to −22 mV, indicating stronger electrostatic repulsion between the NiₓMn_1-xFe₂O₄ MNPs. The substitution of Ni^2 + ions reduces the magnetic moment, as evidenced by a decrease in saturation magnetization and an increase in coercive field. This reduction is further supported by dynamic magnetization measurements, which exhibit an increase in resonance field and a narrower peak-to-peak linewidth. These changes are attributed to the replacement of Mn²⁺ ions by Ni²⁺ ions, which suppresses the superexchange interaction between Mn²⁺-O-Fe³ ⁺ ions. Furthermore, the self-heating efficiency was evaluated through a specific absorption rate (SAR) under an alternating magnetic field of 9.5 kA/m. Among NiₓMn_1-xFe₂O₄ MNFs, the MnFe₂O₄ achieves the highest SAR of 129 W/g at a low concentration of 1 mg/mL. Additionally, the calculated Intrinsic Loss Power (ILP) value of Ni_xMn_1-xFe₂O₄ MNFs (2.417–0.277 nHm²kg⁻¹) is comparable to those of medically approved magnetic fluids (3.1–0.15 nHm²kg⁻¹) used in hyperthermia treatments. Consequently, the synthesized NiₓMn_1-xFe₂O₄ MNPs demonstrate the potential for effective cancer treatment at low concentrations (1 mg/mL) and low magnetic fields (9.5 kA/m). The results demonstrated that NiₓMn_1-xFe₂O₄ MNPs generated localized heating suitable for hyperthermic cancer treatments.

查看原文本刊更多论文

为了寻找一种用于热疗的最佳散热水性磁性纳米流体（MNFs），研究人员采用新型超声辅助反向化学共沉淀法合成了包覆 PEG-400 的镍ₓMn1-xFe₂O₄（0 ≤ x ≤ 0.8）磁性纳米粒子（MNPs）。镍ₓMn1-xFe₂O₄ MNPs 的里特维尔德精制 X 射线衍射图样表明其为单相，晶粒大小在 28 纳米到 40 纳米之间。X 射线光电子能谱（XPS）分析进一步揭示了 Ni²⁺、Fe³⁺ 和 Mn²⁺ 离子的表面组成和氧化态。胶体稳定性体现在 Zeta 电位（ζ）的增加，从 -59 mV 到 -22 mV，这表明 NiₓMn1-xFe₂O₄ MNPs 之间的静电排斥更强。Ni2 + 离子的取代降低了磁矩，这表现在饱和磁化的降低和矫顽力场的增加。动态磁化测量进一步证实了磁矩的降低，测量结果显示共振场增加，峰峰线宽变窄。这些变化归因于 Ni²⁺ 离子取代了 Mn²⁺ 离子，从而抑制了 Mn²⁺-O-Fe³ ⁺ 离子之间的超交换相互作用。此外，还通过 9.5 kA/m 交变磁场下的比吸收率（SAR）对自热效率进行了评估。在 NiₓMn1-xFe₂O₄ MNFs 中，MnFe2O4 在 1 mg/mL 的低浓度下达到了最高的 SAR，为 129 W/g。此外，计算得出的 NixMn1-xFe2O4 MNFs 本征损耗功率（ILP）值（2.417-0.277 nHm2kg-1）与医学上批准用于热疗的磁性流体（3.1-0.15 nHm2kg-1）相当。因此，合成的镍ₓMn1-xFe₂O₄ MNPs 证明了在低浓度（1 mg/mL）和低磁场（9.5 kA/m）条件下有效治疗癌症的潜力。结果表明，NiₓMn1-xFe2O4 MNPs 能产生局部加热，适合热疗癌症。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Colloids and Surfaces A: Physicochemical and Engineering Aspects 化学-物理化学

CiteScore

8.70

自引率

9.60%

发文量

2421

审稿时长

56 days

期刊介绍： Colloids and Surfaces A: Physicochemical and Engineering Aspects is an international journal devoted to the science underlying applications of colloids and interfacial phenomena. The journal aims at publishing high quality research papers featuring new materials or new insights into the role of colloid and interface science in (for example) food, energy, minerals processing, pharmaceuticals or the environment.