Effects of inspiratory muscle metaboreflex on cerebral circulation at rest and during light-intensity exercise in healthy males

IF 1.9 4区医学 Q3 PHYSIOLOGY

Respiratory Physiology & Neurobiology Pub Date : 2025-03-26 DOI:10.1016/j.resp.2025.104422

Kohei Sato , Tatsuki Kamoda , Rintaro Sakamoto , Keisho Katayama , Toru Neki , Masaki Katayose , Erika Iwamoto

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引用次数: 0

Abstract

Purpose

This study aimed to clarify the effects of inspiratory muscle metaboreflex on cerebral circulation at rest and during exercise.

Methods

Twelve young males randomly completed two trials (rest and exercise [leg cycling at 40 % peak oxygen uptake] trials) on separate days. In each trial, the internal carotid artery (ICA), an index of cerebral circulation, was measured using Doppler ultrasound 2 min after inspiratory loading breathing (IL condition) or non-loading breathing (control condition). During ICA assessments, participants engaged in 3 min of spontaneous breathing (SB), followed by 3 min of isocapnic hyperventilation (IHV).

Results

ICA conductance was lower in the IL condition than in the control condition in both rest and exercise trials. Inspiratory muscle metaboreflex did not reduce ICA blood flow during SB but decreased it during IHV in both trials.

Conclusion

Our findings suggest that inspiratory muscle metaboreflex could decrease cerebrovascular conductance from rest to light-intensity exercise and attenuates cerebral blood flow with increased respiratory muscle work.

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来源期刊

Respiratory Physiology & Neurobiology 医学-呼吸系统

CiteScore

4.80

自引率

8.70%

发文量

104

审稿时长

54 days

期刊介绍： Respiratory Physiology & Neurobiology (RESPNB) publishes original articles and invited reviews concerning physiology and pathophysiology of respiration in its broadest sense. Although a special focus is on topics in neurobiology, high quality papers in respiratory molecular and cellular biology are also welcome, as are high-quality papers in traditional areas, such as: -Mechanics of breathing- Gas exchange and acid-base balance- Respiration at rest and exercise- Respiration in unusual conditions, like high or low pressure or changes of temperature, low ambient oxygen- Embryonic and adult respiration- Comparative respiratory physiology. Papers on clinical aspects, original methods, as well as theoretical papers are also considered as long as they foster the understanding of respiratory physiology and pathophysiology.