Metabolic reprogramming of tumor microenviroment by engineered bacteria

IF 12.1 1区医学 Q1 ONCOLOGY

Seminars in cancer biology Pub Date : 2025-03-27 DOI:10.1016/j.semcancer.2025.03.003

Heng Wang, Fang Xu, Chao Wang

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Abstract

The tumor microenvironment (TME) is a complex ecosystem that plays a crucial role in tumor progression and response to therapy. The metabolic characteristics of the TME are fundamental to its function, influencing not only cancer cell proliferation and survival but also the behavior of immune cells within the tumor. Metabolic reprogramming—where cancer cells adapt their metabolic pathways to support rapid growth and immune evasion—has emerged as a key factor in cancer immunotherapy. Recently, the potential of engineered bacteria in cancer immunotherapy has gained increasing recognition, offering a novel strategy to modulate TME metabolism and enhance antitumor immunity. This review summarizes the metabolic properties and adaptations of tumor and immune cells within the TME and summarizes the strategies by which engineered bacteria regulate tumor metabolism. We discuss how engineered bacteria can overcome the immunosuppressive TME by reprogramming its metabolism to improve antitumor therapy. Furthermore, we examine the advantages, potential challenges, and future clinical translation of engineered bacteria in reshaping TME metabolism.

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利用工程细菌对肿瘤微环境进行代谢重编程

肿瘤微环境（TME）是一个复杂的生态系统，在肿瘤的进展和治疗反应中起着至关重要的作用。TME的代谢特性是其功能的基础，不仅影响癌细胞的增殖和存活，还影响肿瘤内免疫细胞的行为。代谢重编程-癌细胞调整其代谢途径以支持快速生长和免疫逃避-已成为癌症免疫治疗的关键因素。近年来，工程细菌在肿瘤免疫治疗中的潜力越来越受到重视，为调节TME代谢和增强抗肿瘤免疫提供了一种新的策略。本文综述了肿瘤和免疫细胞在TME中的代谢特性和适应性，并总结了工程细菌调节肿瘤代谢的策略。我们讨论了工程细菌如何通过重编程其代谢来克服免疫抑制TME，以提高抗肿瘤治疗。此外，我们还研究了工程细菌在重塑TME代谢方面的优势、潜在挑战和未来的临床转化。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Seminars in cancer biology 医学-肿瘤学

CiteScore

26.80

自引率

4.10%

发文量

347

审稿时长

15.1 weeks

期刊介绍： Seminars in Cancer Biology (YSCBI) is a specialized review journal that focuses on the field of molecular oncology. Its primary objective is to keep scientists up-to-date with the latest developments in this field. The journal adopts a thematic approach, dedicating each issue to an important topic of interest to cancer biologists. These topics cover a range of research areas, including the underlying genetic and molecular causes of cellular transformation and cancer, as well as the molecular basis of potential therapies. To ensure the highest quality and expertise, every issue is supervised by a guest editor or editors who are internationally recognized experts in the respective field. Each issue features approximately eight to twelve authoritative invited reviews that cover various aspects of the chosen subject area. The ultimate goal of each issue of YSCBI is to offer a cohesive, easily comprehensible, and engaging overview of the selected topic. The journal strives to provide scientists with a coordinated and lively examination of the latest developments in the field of molecular oncology.