Recent advancement on metal free hydroamination reaction of C–C multiple bonds

IF 2.1 3区化学 Q2 CHEMISTRY, ORGANIC

Tetrahedron Pub Date : 2025-03-28 DOI:10.1016/j.tet.2025.134625

Pamela Pal , Sayanti Show , Sukanya Das , Sriyanka Bhandari , Sushmita Nandy , Md. Abbasuddin Sk , Raj Kumar Nandi

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Abstract

Hydroamination is an essential tool in organic synthesis because it facilitates the addition of amines to unsaturated hydrocarbons. Metal-free hydroamination reactions are a significant advancement in organic synthesis, enabling for both intra- and intermolecular processes employing unactivated C–C multiple bonds to form C–N bonds. We documented the reported literature methods, which provided an environmentally acceptable and cost-effective alternative to standard metal-catalyzed hydroamination reactions. This review focuses on the substrate range, functional group tolerance, and mechanistic understanding of diverse tactics, such as the utilization of Lewis acids, organic bases, iodine catalysts, photochemical and electrochemical approaches. Finally, this review aims to provide an in-depth analysis of the most recent advances in metal-free hydroamination reported between 2014 and 2024, highlighting its promise for sustainable chemistry with an emphasis on the production of fine chemicals and pharmaceutically impactful products.

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来源期刊

Tetrahedron 化学-有机化学

CiteScore

3.90

自引率

4.80%

发文量

439

审稿时长

34 days

期刊介绍： Tetrahedron publishes full accounts of research having outstanding significance in the broad field of organic chemistry and its related disciplines, such as organic materials and bio-organic chemistry. Regular papers in Tetrahedron are expected to represent detailed accounts of an original study having substantially greater scope and details than that found in a communication, as published in Tetrahedron Letters. Tetrahedron also publishes thematic collections of papers as special issues and ''Reports'', commissioned in-depth reviews providing a comprehensive overview of a research area.