A heterogeneous MOF-253-based Pd/Cu bimetal for Sonogashira coupling reactions

IF 2.1 3区化学 Q2 CHEMISTRY, ORGANIC

Tetrahedron Pub Date : 2025-03-29 DOI:10.1016/j.tet.2025.134628

Ningtao Cao , Yue Tong , Jianwei Xie , Shaofeng Gong

引用次数: 0

Abstract

Here we reported a MOF-based bimetal catalyst, Cu-MOF-253-Pd, as an efficient, robust and recyclable catalyst for Sonogashira coupling reaction between (hetero)aryl halides and terminal alkynes for the preparation of di-substituted acetylenes. Broad substrate scope, including late-stage functionalization of complex molecule, has been demonstrated, and the synthetic applications further displayed high turnover numbers up to 4794, scalability, recyclability and robustness of the reaction system.

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来源期刊

Tetrahedron 化学-有机化学

CiteScore

3.90

自引率

4.80%

发文量

439

审稿时长

34 days

期刊介绍： Tetrahedron publishes full accounts of research having outstanding significance in the broad field of organic chemistry and its related disciplines, such as organic materials and bio-organic chemistry. Regular papers in Tetrahedron are expected to represent detailed accounts of an original study having substantially greater scope and details than that found in a communication, as published in Tetrahedron Letters. Tetrahedron also publishes thematic collections of papers as special issues and ''Reports'', commissioned in-depth reviews providing a comprehensive overview of a research area.