Clinical evaluation of safety and efficacy of biozen syrup in patients with hyperlipidemia

Q2 Medicine

Obesity Medicine Pub Date : 2025-03-21 DOI:10.1016/j.obmed.2025.100601

Rajappan Chandra Satish Kumar , Subramaniam Nandhini , Bhuvaneshwaran Mothishwaran , Chittaranjan Das , Anavarathan Vallipuram , Muhasaparur Ganesan Rajanandh

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引用次数: 0

Abstract

Background

The increasing prevalence of hyperlipidemia has become one of the greatest threats to public health. While pharmacological treatments are effective for the management of hyperlipidemia, alternative approaches like dietary supplements are gaining interest for their natural benefits. The present study aimed to evaluate the safety and efficacy of biozen syrup comprised of garlic, apple-cider vinegar, lemon and honey for controlling patients with hyperlipidemia.

Methods

A prospective, open-label study was conducted on patients who had hyperlipidemia. Patients were given with biozen syrup (15 ml in 100 ml warm water) twice daily for 90 days. Clinical assessments and laboratory findings were compared before (day 0) and after (day 90) starting the treatment.

Results

A total of 60 patients were enrolled in the study. After administration of biozen syrup, serum total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), very low-density lipoprotein cholesterol (VLDL-C), high-sensitivity C-reactive protein (hs-CRP), homocysteine, and apolipoprotein B levels significantly decreased (p < 0.001). The mean serum apolipoprotein A1, high-density lipoprotein cholesterol (HDL-C) were raised post-treatment (p < 0.001). Treatment with biozen syrup had no significant effects (p > 0.001) on serum biochemical parameters related to liver, kidney functions and hematological parameters. Gastrointestinal disturbances was the most frequently occurred ADR (58 %).

Conclusion

The results demonstrated that the biozen was safe and efficacious in lowering the levels of bad cholesterol and raising the levels of good cholesterol.

Abstract Image

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biozen糖浆治疗高脂血症的安全性和有效性的临床评价

背景：高脂血症的日益流行已成为公众健康的最大威胁之一。虽然药物治疗对高脂血症的治疗是有效的，但像膳食补充剂这样的替代方法因其天然的益处而受到关注。本研究旨在评价由大蒜、苹果醋、柠檬和蜂蜜组成的biozen糖浆控制高脂血症患者的安全性和有效性。方法对高脂血症患者进行前瞻性、开放标签研究。患者每日2次给予biozen糖浆（15 ml放入100 ml温水中），连续90天。比较治疗开始前（第0天）和治疗开始后（第90天）的临床评估和实验室结果。结果共纳入60例患者。给药后，血清总胆固醇（TC）、甘油三酯（TG）、低密度脂蛋白胆固醇（LDL-C）、极低密度脂蛋白胆固醇（VLDL-C）、高敏c反应蛋白（hs-CRP）、同型半胱氨酸和载脂蛋白B水平显著降低(p <；0.001)。治疗后血清载脂蛋白A1、高密度脂蛋白胆固醇（HDL-C）均升高(p <；0.001)。用生化糖浆治疗无显著效果(p >；0.001)对肝肾功能相关生化指标和血液学指标的影响。胃肠道紊乱是最常见的不良反应（58%）。结论该制剂具有降低坏胆固醇、提高好胆固醇的作用，安全有效。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Obesity Medicine Medicine-Public Health, Environmental and Occupational Health

CiteScore

5.50

自引率

0.00%

发文量

审稿时长

40 days

期刊介绍： The official journal of the Shanghai Diabetes Institute Obesity is a disease of increasing global prevalence with serious effects on both the individual and society. Obesity Medicine focusses on health and disease, relating to the very broad spectrum of research in and impacting on humans. It is an interdisciplinary journal that addresses mechanisms of disease, epidemiology and co-morbidities. Obesity Medicine encompasses medical, societal, socioeconomic as well as preventive aspects of obesity and is aimed at researchers, practitioners and educators alike.