NMR-based metabolomics unveils the potential mechanism of tetrahydroxy stilbene glycoside in combating D-galactose-induced aging in rats

IF 1.3 4区生物学 Q4 CHEMISTRY, MEDICINAL

Phytochemistry Letters Pub Date : 2025-04-01 DOI:10.1016/j.phytol.2025.102955

Minghui Li , Hui Chai , Tianxiang Chao , Jianye Huang , Limin Han , Qingwang Liu , Lu Yang

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引用次数: 0

Abstract

Aging represents a significant threat to human health, underscoring the critical need for effective anti-aging interventions. In this study, we utilized a comprehensive approach combining ¹H NMR-based metabolomics, serum biochemical analysis, and liver histopathology to evaluate the protective effects of tetrahydroxy stilbene glycoside (TSG) on D-galactose-induced aging in rats. Our findings demonstrate that TSG significantly enhances antioxidant activity and alleviates D-galactose-induced liver damage. Metabolomic analysis revealed increased levels in 3-hydroxybutyrate, succinate, and tryptophan, alongside decreased levels in alanine, arginine, and acetate, in the serum of aging rats. TSG treatment effectively reversed these metabolic perturbations. Further pathway analysis indicated that TSG restored balance in several key metabolic pathways, such as phenylalanine and tyrosine metabolism, betaine metabolism, carnitine synthesis, and methionine metabolism. In summary, TSG not only bolstered antioxidant defenses and alleviated liver injury but also normalized metabolic dysregulation in aging rats. These findings highlight TSG's potential as a promising anti-aging agent and support its further exploration for clinical applications.

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来源期刊

Phytochemistry Letters 生物-生化与分子生物学

CiteScore

3.00

自引率

11.80%

发文量

190

审稿时长

34 days

期刊介绍： Phytochemistry Letters invites rapid communications on all aspects of natural product research including: • Structural elucidation of natural products • Analytical evaluation of herbal medicines • Clinical efficacy, safety and pharmacovigilance of herbal medicines • Natural product biosynthesis • Natural product synthesis and chemical modification • Natural product metabolism • Chemical ecology • Biotechnology • Bioassay-guided isolation • Pharmacognosy • Pharmacology of natural products • Metabolomics • Ethnobotany and traditional usage • Genetics of natural products Manuscripts that detail the isolation of just one new compound are not substantial enough to be sent out of review and are out of scope. Furthermore, where pharmacology has been performed on one new compound to increase the amount of novel data, the pharmacology must be substantial and/or related to the medicinal use of the producing organism.