Polyphenol-regulated Cu-based broad-spectrum anti-oxidants to overcome oxidative stress

IF 6.5 2区材料科学 Q1 MATERIALS SCIENCE, COMPOSITES

Composites Communications Pub Date : 2025-03-30 DOI:10.1016/j.coco.2025.102385

Ke Zhang, Minghui Ou, Yujie Xiao, Zhiwei Wei, Li Yang, Yi Xie, Changsheng Zhao

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引用次数: 0

Abstract

Copper-based nanozymes have emerged as promising therapeutic agents for oxidative stress-related diseases due to their enzyme-mimicking properties. However, their development is still limited by poor biocompatibility, insufficient broad-spectrum free radical scavenging ability, and potential toxicity from Cu²⁺ leakage. To address these challenges, we developed Cu@EA-BTC, a broad-spectrum antioxidant material, by integrating ellagic acid (EA) into copper-based metal-organic frameworks (Cu@BTC). The Cu@BTC serves as a stable copper source, while the EA endows the Cu@EA-BTC with broad-spectrum ROS scavenging and enhanced catalase (CAT)-like activity via facilitating the reduction of Cu²⁺ to Cu⁺. As a result, the Cu@EA-BTC exhibits superior antioxidant properties and excellent biocompatibility, including both cellular and blood compatibility. Meanwhile, the Cu@EA-BTC effectively protects immune cells from oxidative damage, which indicates its potential for oxidative stress-related therapies. This study provides a promising strategy for developing safe and efficient nanozyme-based antioxidant materials for biomedical applications.

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多酚调节铜基广谱抗氧化剂克服氧化应激

铜基纳米酶由于其酶模拟特性而成为治疗氧化应激相关疾病的有前途的药物。然而，它们的发展仍然受到生物相容性差，广谱自由基清除能力不足以及Cu2+泄漏的潜在毒性的限制。为了应对这些挑战，我们开发了Cu@EA-BTC，一种广谱抗氧化材料，通过将鞣花酸（EA）整合到铜基金属有机框架中（Cu@BTC）。Cu@BTC作为稳定的铜源，而EA通过促进Cu2+还原为Cu+，赋予Cu@EA-BTC广谱ROS清除和增强过氧化氢酶（CAT）样活性。因此，Cu@EA-BTC具有优异的抗氧化性能和良好的生物相容性，包括细胞和血液相容性。同时，Cu@EA-BTC有效地保护免疫细胞免受氧化损伤，这表明其潜在的氧化应激相关治疗。本研究为开发安全高效的纳米酶基生物医学抗氧化材料提供了一条有前景的途径。

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来源期刊

Composites Communications Materials Science-Ceramics and Composites

CiteScore

12.10

自引率

10.00%

发文量

340

审稿时长

36 days

期刊介绍： Composites Communications (Compos. Commun.) is a peer-reviewed journal publishing short communications and letters on the latest advances in composites science and technology. With a rapid review and publication process, its goal is to disseminate new knowledge promptly within the composites community. The journal welcomes manuscripts presenting creative concepts and new findings in design, state-of-the-art approaches in processing, synthesis, characterization, and mechanics modeling. In addition to traditional fiber-/particulate-reinforced engineering composites, it encourages submissions on composites with exceptional physical, mechanical, and fracture properties, as well as those with unique functions and significant application potential. This includes biomimetic and bio-inspired composites for biomedical applications, functional nano-composites for thermal management and energy applications, and composites designed for extreme service environments.