Afamin and Apolipoprotein F Associated With Liver Steatosis From People Living With HIV: A Discovery Study

IF 6.6 1区医学 Q1 GASTROENTEROLOGY & HEPATOLOGY

Alimentary Pharmacology & Therapeutics Pub Date : 2025-03-30 DOI:10.1111/apt.70119

Mario Frías, Eduardo Chicano-Gálvez, Antonio Rivero-Juárez, Ana Gordon, Diana Corona-Mata, José María Moyano, Ángela Peralbo-Molina, Ángela Camacho, Ignacio Pérez-Valero, María del Mar Malagón, Antonio Rivero

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Abstract

Introduction

Liver steatosis (LS) is a condition that is characterised by hepatic fat accumulation unrelated to significant alcohol consumption. This study explored the serum proteomic profile associated with LS in people living with HIV (PLWH).

Methods

The study cohort comprised 266 PLWH, 21.1% and 78.9% of whom had LS and no LS, respectively. Serum samples were analysed using liquid chromatography coupled with mass spectrometry (LC–MS).

Results

Among the 220 proteins detected, afamin (AFM) and apolipoprotein F (APOF) were identified as proteins associated with LS. Differential expression of AFM and APOF was observed in under- and normoweight patients, emphasising their potential as biomarkers in patients without overweight or obesity.

Conclusions

These findings suggest that the identified proteins could serve as promising biomarkers of LS in PLWH, paving the way for further investigations into the roles of these proteins in LS development in this unique population.

Abstract Image

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与HIV感染者肝脂肪变性相关的维生素和载脂蛋白F：一项发现研究

肝脂肪变性（LS）是一种以肝脏脂肪堆积为特征的疾病，与大量饮酒无关。本研究探讨了HIV感染者（PLWH）与LS相关的血清蛋白质组学特征。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Alimentary Pharmacology & Therapeutics 医学-胃肠肝病学

CiteScore

15.60

自引率

7.90%

发文量

527

审稿时长

3-6 weeks

期刊介绍： Alimentary Pharmacology & Therapeutics is a global pharmacology journal focused on the impact of drugs on the human gastrointestinal and hepato-biliary systems. It covers a diverse range of topics, often with immediate clinical relevance to its readership.