Khalid Khadawardi, Mohammed Abuzaid, Saeed Baradwan, Saud Owaimer Alsehaimi, Hedaya Albelwi, Seham Adel Arishi, Mooza M Alzayed, Osama Alomar, Ahmed Abu-Zaid
{"title":"High Maternal Serum Uric Acid Levels and Risk of Low-Birth-Weight and Small for Gestational Age Infant: A Systematic Review and Meta-Analysis.","authors":"Khalid Khadawardi, Mohammed Abuzaid, Saeed Baradwan, Saud Owaimer Alsehaimi, Hedaya Albelwi, Seham Adel Arishi, Mooza M Alzayed, Osama Alomar, Ahmed Abu-Zaid","doi":"10.1007/s43032-025-01853-3","DOIUrl":null,"url":null,"abstract":"<p><p>Although the association between high uric acid levels and adverse pregnancy outcomes has been explored, the effects of elevated uric acid levels on the risk of low-birth-weight (LBW) and small for gestational age (SGA) remain unclear. Therefore, this systematic review and meta-analysis aimed to investigate the relationship between uric acid levels during pregnancy and the risk of LBW. PubMed, Scopus, Cochrane central and Web of Science databases were searched up to September 2024 for relevant observational studies. A random effects model was used to estimate pooled odds ratios (OR) and 95% confidence intervals (95% CI). To assess the heterogeneity of included studies, the I<sup>2</sup> index was used. Finally, 29 observational studies were eligible for inclusion in this meta-analysis. Pooled analysis showed that higher uric acid levels significantly increased the risk of LBW (OR = 2.28, 95% CI: 1.62-3.22, P < 0.001; I<sup>2</sup> = 93.14%, n = 21 studies) and SGA (OR = 1.77, 95% CI 1.38-2.27, P < 0.001, I<sup>2</sup> = 91.67%, n = 14 studies). However, there was no significant effect of high uric acid levels and macrosomia (OR = 1.29, 95% CI 0.52-3.18, P = 0.59, I<sup>2</sup> = 71.86%, n = 3 studies). This study demonstrated a positive association between uric acid levels and the risk of LBW and SGA. It appears that elevated uric acid can significantly impact neonatal health, highlighting the critical importance of uric acid monitoring during pregnancy.</p>","PeriodicalId":20920,"journal":{"name":"Reproductive Sciences","volume":" ","pages":"1803-1812"},"PeriodicalIF":2.6000,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Reproductive Sciences","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s43032-025-01853-3","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/3/28 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"OBSTETRICS & GYNECOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Although the association between high uric acid levels and adverse pregnancy outcomes has been explored, the effects of elevated uric acid levels on the risk of low-birth-weight (LBW) and small for gestational age (SGA) remain unclear. Therefore, this systematic review and meta-analysis aimed to investigate the relationship between uric acid levels during pregnancy and the risk of LBW. PubMed, Scopus, Cochrane central and Web of Science databases were searched up to September 2024 for relevant observational studies. A random effects model was used to estimate pooled odds ratios (OR) and 95% confidence intervals (95% CI). To assess the heterogeneity of included studies, the I2 index was used. Finally, 29 observational studies were eligible for inclusion in this meta-analysis. Pooled analysis showed that higher uric acid levels significantly increased the risk of LBW (OR = 2.28, 95% CI: 1.62-3.22, P < 0.001; I2 = 93.14%, n = 21 studies) and SGA (OR = 1.77, 95% CI 1.38-2.27, P < 0.001, I2 = 91.67%, n = 14 studies). However, there was no significant effect of high uric acid levels and macrosomia (OR = 1.29, 95% CI 0.52-3.18, P = 0.59, I2 = 71.86%, n = 3 studies). This study demonstrated a positive association between uric acid levels and the risk of LBW and SGA. It appears that elevated uric acid can significantly impact neonatal health, highlighting the critical importance of uric acid monitoring during pregnancy.
虽然高尿酸水平与不良妊娠结局之间的关系已被探讨,但高尿酸水平对低出生体重(LBW)和小胎龄(SGA)风险的影响仍不清楚。因此,本系统综述和荟萃分析旨在探讨妊娠期间尿酸水平与LBW风险之间的关系。检索PubMed、Scopus、Cochrane central和Web of Science数据库,检索截至2024年9月的相关观察性研究。随机效应模型用于估计合并优势比(OR)和95%置信区间(95% CI)。为了评估纳入研究的异质性,使用I2指数。最后,29项观察性研究符合纳入本荟萃分析的条件。合并分析显示,较高的尿酸水平显著增加了LBW (OR = 2.28, 95% CI: 1.62-3.22, P 2 = 93.14%, n = 21项研究)和SGA (OR = 1.77, 95% CI 1.38-2.27, P 2 = 91.67%, n = 14项研究)的风险。然而,高尿酸水平和巨大儿没有显著影响(OR = 1.29, 95% CI 0.52-3.18, P = 0.59, I2 = 71.86%, n = 3项研究)。该研究表明尿酸水平与LBW和SGA的风险呈正相关。尿酸升高似乎会显著影响新生儿健康,这凸显了孕期尿酸监测的重要性。
期刊介绍:
Reproductive Sciences (RS) is a peer-reviewed, monthly journal publishing original research and reviews in obstetrics and gynecology. RS is multi-disciplinary and includes research in basic reproductive biology and medicine, maternal-fetal medicine, obstetrics, gynecology, reproductive endocrinology, urogynecology, fertility/infertility, embryology, gynecologic/reproductive oncology, developmental biology, stem cell research, molecular/cellular biology and other related fields.