Predictive value of cumulative SII for MACE in STEMI patients after PCI.

IF 1.3 4区 医学 Q2 MEDICINE, GENERAL & INTERNAL
Weifeng Zhang, Haiyan Jia, Xingzhou Zhao, Wanqing Song, Weiwei Sun, Qianyi Wang, Yanling Li, Xiaowei Wang
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Abstract

The systemic immune-inflammation index (SII) has been used effectively to effectively assess the prognosis of patients with a variety of diseases. But few evidence on the relationship between SII and long-term prognosis of myocardial infarction. We thus aimed to evaluate the relationships of cumulative exposure to SII and its accumulation time course with major adverse cardiovascular events (MACE) events in patients with acute myocardial infarction after percutaneous coronary intervention. To evaluate the predictive value of SII in MACE events in patients with acute myocardial infarction. A total of 480 patients with acute ST-elevation myocardial infarction who underwent emergency coronary angiography at the Department of Cardiology, Affiliated Hospital of Hebei University from August 2022 to August 2023 were enrolled in this study. Eighteen patients were lost to follow-up, with a loss rate of 3.8%. Time-weighted cumulative SII was calculated as the weighted sum of the mean SII value for each time interval, then normalized by total exposure duration, the exposure duration was from hospitalization to 1-year follow-up. Duration of high SII exposure was defined as the duration with high SII and ranged from hospitalization to 1-year follow-up. The time course of SII accumulation was categorized by the combination of time-weighted cumulative SII < or ≥ median and SII slope. At 1-year follow-up, after adjusting for potential confounders, the time-weighted cumulative SII was divided into 2 groups. The S2 group which is above the median had a higher risk of MACE (hazard ratio, 1.090; 95% confidence interval 1.035-1.149), the high time-weighted cumulative SII group with a positive slope had a higher risk of MACE (hazard ratio, 4.096; 95% confidence interval 1.851-9.065). Long-term cumulative exposure to SII increases the risk of MACE in patients with acute ST-elevation myocardial infarction undergoing coronary angiography, and late high SII results in a higher risk of MACE events at the same time-weighted cumulative SII, underscoring the importance of late inflammation control.

全身免疫炎症指数(SII)已被有效用于评估多种疾病患者的预后。但有关 SII 与心肌梗死长期预后关系的证据却很少。因此,我们旨在评估经皮冠状动脉介入治疗后急性心肌梗死患者的 SII 累积暴露量及其累积时间过程与主要不良心血管事件(MACE)的关系。评估 SII 对急性心肌梗死患者 MACE 事件的预测价值。本研究共纳入了480例2022年8月至2023年8月期间在河北大学附属医院心内科接受急诊冠状动脉造影术的急性ST段抬高型心肌梗死患者。18 名患者失去了随访机会,失去率为 3.8%。时间加权累积 SII 计算为每个时间间隔的平均 SII 值的加权和,然后按总暴露持续时间归一化,暴露持续时间为住院至 1 年随访。高 SII 暴露持续时间定义为具有高 SII 的持续时间,范围从住院到 1 年随访。SII 积累的时间过程根据时间加权的累积 SII
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来源期刊
Medicine
Medicine 医学-医学:内科
CiteScore
2.80
自引率
0.00%
发文量
4342
审稿时长
>12 weeks
期刊介绍: Medicine is now a fully open access journal, providing authors with a distinctive new service offering continuous publication of original research across a broad spectrum of medical scientific disciplines and sub-specialties. As an open access title, Medicine will continue to provide authors with an established, trusted platform for the publication of their work. To ensure the ongoing quality of Medicine’s content, the peer-review process will only accept content that is scientifically, technically and ethically sound, and in compliance with standard reporting guidelines.
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