{"title":"Comprehensive analysis of GDFs as therapeutic targets and prognosis biomarkers in gastric cancer.","authors":"Minjie Zhu, Jiawei Hong, Xianfang Liu, Haiming Wang, Longquan Lou","doi":"10.1097/MD.0000000000041976","DOIUrl":null,"url":null,"abstract":"<p><p>Growth/differentiation factors (GDFs, GDF1-3, GDF5-7, GDF9-11, and GDF15) belong to a subfamily of the transforming growth factor-β. GDFs play an important role in morphogenetic and developmental activities in many tissues. And many GDFs family numbers have been observed to be correlated with various types of tumors. However, the diverse expression patterns and prognostic values of ten GDFs in gastric cancer (GC) have yet to be analyzed. Herein we investigated the transcriptional and survival data of GDFs in patients with GC from the Gene Expression Profiling Interactive Analysis, The Cancer Genome Atlas, cBioPortal, Tumor Immune Estimation Resource, Tumor Immune Syngeneic Mouse, UALCAN, Human Protein Atlas Gene Expression Omnibus and The Database for Annotation, Visualization and Integrated Discovery databases. We found that multiple GDF family members are highly expressed in GC, which can prompt diagnosis and evaluate prognosis, and can be used as target points for GC immunotherapy.</p>","PeriodicalId":18549,"journal":{"name":"Medicine","volume":"104 13","pages":"e41976"},"PeriodicalIF":1.3000,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11957613/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Medicine","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1097/MD.0000000000041976","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}
引用次数: 0
Abstract
Growth/differentiation factors (GDFs, GDF1-3, GDF5-7, GDF9-11, and GDF15) belong to a subfamily of the transforming growth factor-β. GDFs play an important role in morphogenetic and developmental activities in many tissues. And many GDFs family numbers have been observed to be correlated with various types of tumors. However, the diverse expression patterns and prognostic values of ten GDFs in gastric cancer (GC) have yet to be analyzed. Herein we investigated the transcriptional and survival data of GDFs in patients with GC from the Gene Expression Profiling Interactive Analysis, The Cancer Genome Atlas, cBioPortal, Tumor Immune Estimation Resource, Tumor Immune Syngeneic Mouse, UALCAN, Human Protein Atlas Gene Expression Omnibus and The Database for Annotation, Visualization and Integrated Discovery databases. We found that multiple GDF family members are highly expressed in GC, which can prompt diagnosis and evaluate prognosis, and can be used as target points for GC immunotherapy.
生长/分化因子（GDFs、GDF1-3、GDF5-7、GDF9-11和GDF15）属于转化生长因子-β的一个亚家族。GDFs在许多组织的形态发生和发育活动中起着重要作用。许多GDFs家族数量已被观察到与各种类型的肿瘤相关。然而，10种gdf在胃癌（GC）中的不同表达模式和预后价值尚未得到分析。本文研究了来自基因表达谱交互分析、癌症基因组图谱、cBioPortal、肿瘤免疫估计资源、肿瘤免疫同基因小鼠、UALCAN、人类蛋白质图谱基因表达Omnibus和the Database for Annotation、Visualization和Integrated Discovery数据库的胃癌患者GDFs的转录和生存数据。我们发现多个GDF家族成员在GC中高表达，可以提示诊断和评估预后，可以作为GC免疫治疗的靶点。
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