Effect of Regular Exercise on Cognitive Frailty in the Elderly: A Systematic Review.

IF 1.4 4区 医学 Q4 GERIATRICS & GERONTOLOGY
Wenting Ji, Liwei Sun, Qian Geng, Guohua Zheng
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引用次数: 0

Abstract

Objectives: As one of the common senile syndromes characterized by the co-existence of physical frailty and cognitive impairment without dementia, the occurrence of cognitive frailty (CF) increases the risk of adverse health outcomes in older adults. However, its reversibility has attracted the interest of researchers in the search for effective interventions. A growing number of studies have been conducted to investigate the effect of regular physical exercise intervention on cognitive frailty in older adults with CF, but findings remain inconclusive. This study aimed to synthesize the pooled effect of current regular exercise intervention in community-dwelling older adults with cognitive frailty.

Methods: Nine electronic databases (Cochrane Library, PubMed, EBSCOHost, Web of Science, Scopus, CNKI, Wanfang Database, VIP and SinoMed) were searched from their inception to 15 May, 2024. The Cochrane risk-of-bias tool (ROB 2) for RCTs was applied to assess the methodological quality. The mean difference or standardized mean difference with 95% CIs was calculated by using Stata 18.0.

Results: Seventeen eligible studies involving a total of 2239 participants were included. The pooled results showed that older adults with CF in the intervention group had significant improvement in global cognitive function performance (MMSE scores: MD = 1.93 95% CI: 1.02 to 2.85, p < .0001, and MoCA scores: MD = 3.24, 95% CI: 1.57 to 4.91, p < .0001), executive function (time of TMT-B test: MD = -20.73, 95% CI: -33.96 to -7.50, p = .002), physical frailty state (Fried frailty phenotype scores: MD = -1.48, 95% CI: -2.37 to -0.58, p = .001, and EFS scores: MD = -0.81 points, 95% CI: -1.13 to -0.49, p < .0001), grip strength (SMD = 0.92, 95% CI: 0.15 to 1.07, p = .02), gait and balance (time of TUG: MD = -2.62, 95% CI: -4.12 to -1.11, p = .001), balance (BBS scores: MD = 8.56, 95% CI:- 3.37 to 13.75, p = .001) and quality of life (SMD = 0.75, 95% CI: 0.30 to 1.21, p = .001).

Conclusions: More than eight weeks of regular exercise interventions may improve global cognitive function and physical frailty status, but the effect on specific domains of cognitive or physical function needs further study to confirm.

有规律的运动对老年人认知衰弱的影响:一项系统综述。
目的:认知衰弱(cognitive fragile, CF)是老年人身体虚弱和认知功能障碍并存的常见老年综合征之一,其发生增加了老年人不良健康结局的风险。然而,其可逆性引起了研究人员寻找有效干预措施的兴趣。越来越多的研究调查了有规律的体育锻炼干预对老年CF患者认知衰弱的影响,但结果仍不确定。本研究旨在综合当前定期运动干预对社区居住的认知衰弱老年人的综合影响。方法:检索自Cochrane Library、PubMed、EBSCOHost、Web of Science、Scopus、CNKI、万方数据库、VIP、中国医学信息网(SinoMed)等9个电子数据库,检索时间为建库至2024年5月15日。采用随机对照试验的Cochrane风险偏倚工具(ROB 2)评估方法学质量。采用Stata 18.0计算95% ci的平均差或标准化平均差。结果:17项符合条件的研究共纳入2239名受试者。综合结果显示,干预组老年CF患者在整体认知功能表现(MMSE评分:MD = 1.93 95% CI: 1.02 ~ 2.85, p p p = 0.002)、身体虚弱状态(Fried脆弱表型评分:MD = -1.48, 95% CI: -2.37 ~ -0.58, p =。EFS评分:MD = -0.81分,95% CI:- 1.13至-0.49,p p = 0.02),步态和平衡(TUG时间:MD = -2.62, 95% CI:- 4.12至-1.11,p = .001),平衡(BBS评分:MD = 8.56, 95% CI:- 3.37至13.75,p = .001)和生活质量(SMD = 0.75, 95% CI: 0.30至1.21,p = .001)。结论:超过8周的常规运动干预可以改善整体认知功能和身体虚弱状态,但对特定领域的认知或身体功能的影响需要进一步研究证实。
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来源期刊
Experimental Aging Research
Experimental Aging Research 医学-老年医学
CiteScore
3.60
自引率
0.00%
发文量
68
审稿时长
>12 weeks
期刊介绍: Experimental Aging Research is a life span developmental and aging journal dealing with research on the aging process from a psychological and psychobiological perspective. It meets the need for a scholarly journal with refereed scientific papers dealing with age differences and age changes at any point in the adult life span. Areas of major focus include experimental psychology, neuropsychology, psychobiology, work research, ergonomics, and behavioral medicine. Original research, book reviews, monographs, and papers covering special topics are published.
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