Exploring the Mechanisms of Testicular Aging: Advances in Biomarker Research.

IF 7 2区医学 Q1 GERIATRICS & GERONTOLOGY

Aging and Disease Pub Date : 2025-03-26 DOI:10.14336/AD.2025.0070

Wenkang Chen, Hede Zou, Haoran Xu, Rui Cao, Yapeng Zhang, Yongjie Ma, Wei Lin, Hekun Zhang, Jiayou Zhao

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引用次数: 0

Abstract

Aging biomarkers quantify aging progression and provide actionable targets for therapeutic interventions to mitigate age-related decline. This review synthesizes emerging evidence on testicular aging biomarkers, focusing on cellular senescence (Leydig, Sertoli, and endothelial cells), protein homeostasis disruption, mitochondrial dysfunction, germ stem cell depletion, sperm telomere length, epigenetic alterations, oxidative stress, inflammation, and gut microbiota dysbiosis. We propose that testicular aging serves as a critical nexus linking reproductive decline with systemic aging processes, with its pathological progression being quantifiable through specific biomarkers including the Leydig, Sertoli, and endothelial cells, INSL3, ribosomal protein RPL39L, sperm telomere length, relative telomere length mitochondrial translocator protein, and sialic acid. By bridging systemic aging paradigms with testis-specific mechanisms, we emphasize the urgency to identify organ-selective biomarkers for targeted interventions, advancing strategies to preserve male fertility and address population aging challenges.

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来源期刊

Aging and Disease GERIATRICS & GERONTOLOGY-

CiteScore

14.60

自引率

2.70%

发文量

138

审稿时长

10 weeks

期刊介绍： Aging & Disease (A&D) is an open-access online journal dedicated to publishing groundbreaking research on the biology of aging, the pathophysiology of age-related diseases, and innovative therapies for conditions affecting the elderly. The scope encompasses various diseases such as Stroke, Alzheimer's disease, Parkinson’s disease, Epilepsy, Dementia, Depression, Cardiovascular Disease, Cancer, Arthritis, Cataract, Osteoporosis, Diabetes, and Hypertension. The journal welcomes studies involving animal models as well as human tissues or cells.