Plasma Insulin-Like Growth Factor Binding Protein-7 is Positively Associated with Age, Obesity, Mortality, and Cancer in Postmenopausal Women.

IF 3.7 3区 医学 Q2 ONCOLOGY
Melissa C Orenduff, Carl F Pieper, Emma H Allott, Michael F Coleman, Su Yon Jung, Mara Z Vitolins, Jenifer I Fenton, Chu Chen, Candyce H Kroenke, Fred K Tabung, Ana Barac, Electra D Paskett, Michael N Pollak, Jennifer Hays-Grudo, Shine Chang, Stephen D Hursting
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引用次数: 0

Abstract

Background: Predictors of premature death and cancer development are needed to more precisely identify individuals who may warrant preventive intervention. Circulating IGF binding protein-7 (IGFBP7) and, to lesser extent, the IGFBP7/IGF-1 ratio are emerging biomarkers of renal and cardiovascular morbidity. However, their relationships with aging, obesity, mortality and cancer risk remain unclear.

Methods: This hypothesis-generating study investigated plasma IGFBP7, IGF-1, and their ratio as predictors of all-cause mortality, any cancer (excluding nonmelanoma skin cancer), obesity-related cancer (composite of 13 cancer types), and breast cancer incidence in a large longitudinal cohort of postmenopausal women. We assessed relationships of each biomarker with age, body mass index (BMI), and each outcome (bivariately and controlling for age, BMI, race, physical activity, education, income, marital status, alcohol intake, smoking, diabetes, and hormone therapy) in 793 Women's Health Initiative-Observational Study participants (mean 19.4 year follow-up).

Results: In adjusted analyses, IGFBP7 increased with age and obesity, and was positively associated with risks of all-cause mortality [hazard ratio (HR)=2.42 (95% CI: 1.37-4.26), p=0.002], any cancer [HR=2.04 (1.05-3.94), p=0.035], and obesity-related cancer [HR=1.58 (0.99-2.51), p=0.053]. Also in adjusted analyses, the IGFBP7/IGF-1 ratio increased with age and was positively associated with all-cause mortality [HR=1.51 (1.14-1.99), p=0.004] and any cancer incidence [HR=5.44 (1.13-26.1), p=0.034].

Conclusions: Plasma IGFBP7 and the IGFBP7/IGF1 ratio are positively associated with age, obesity (IGFBP7 only), mortality, and cancer in postmenopausal women.

Impact: Plasma IGFBP7 may represent an age- and obesity-sensitive biomarker of increased risk of developing cancer and/or dying prematurely.

血浆胰岛素样生长因子结合蛋白-7与绝经后妇女的年龄、肥胖、死亡率和癌症呈正相关
背景:需要早期死亡和癌症发展的预测因子来更准确地识别可能需要预防性干预的个体。循环IGF结合蛋白-7 (IGFBP7)和IGFBP7/IGF-1比值(在较小程度上)是肾脏和心血管疾病的新兴生物标志物。然而,它们与衰老、肥胖、死亡率和癌症风险的关系尚不清楚。方法:这项产生假设的研究调查了血浆IGFBP7、IGF-1及其比值作为全因死亡率、任何癌症(不包括非黑色素瘤皮肤癌)、肥胖相关癌症(13种癌症类型的组合)和乳腺癌发病率的预测因子,研究对象为绝经后妇女的大型纵向队列。我们评估了793名妇女健康主动观察研究参与者(平均随访19.4年)的每个生物标志物与年龄、体重指数(BMI)和每个结果(双变量和控制年龄、BMI、种族、体育活动、教育程度、收入、婚姻状况、饮酒、吸烟、糖尿病和激素治疗)的关系。结果:在校正分析中,IGFBP7随年龄和肥胖增加而增加,并与全因死亡风险呈正相关[危险比(HR)=2.42 (95% CI: 1.37-4.26), p=0.002]、任何癌症[HR=2.04 (1.05-3.94), p=0.035]和肥胖相关癌症[HR=1.58 (0.99-2.51), p=0.053]。同样在校正分析中,IGFBP7/IGF-1比值随着年龄的增长而增加,并与全因死亡率[HR=1.51 (1.14-1.99), p=0.004]和任何癌症发病率[HR=5.44 (1.13-26.1), p=0.034]呈正相关。结论:绝经后妇女血浆IGFBP7和IGFBP7/IGF1比值与年龄、肥胖(仅IGFBP7)、死亡率和癌症呈正相关。影响:血浆IGFBP7可能是一种年龄和肥胖敏感的生物标志物,可增加患癌症和/或过早死亡的风险。
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来源期刊
Cancer Epidemiology Biomarkers & Prevention
Cancer Epidemiology Biomarkers & Prevention 医学-公共卫生、环境卫生与职业卫生
CiteScore
6.50
自引率
2.60%
发文量
538
审稿时长
1.6 months
期刊介绍: Cancer Epidemiology, Biomarkers & Prevention publishes original peer-reviewed, population-based research on cancer etiology, prevention, surveillance, and survivorship. The following topics are of special interest: descriptive, analytical, and molecular epidemiology; biomarkers including assay development, validation, and application; chemoprevention and other types of prevention research in the context of descriptive and observational studies; the role of behavioral factors in cancer etiology and prevention; survivorship studies; risk factors; implementation science and cancer care delivery; and the science of cancer health disparities. Besides welcoming manuscripts that address individual subjects in any of the relevant disciplines, CEBP editors encourage the submission of manuscripts with a transdisciplinary approach.
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