Multi-functional Ag2O-NiO composite bio-catalyst: Efficacy in breast cancer and anti-microbial properties

Next Materials Pub Date : 2025-03-29 DOI:10.1016/j.nxmate.2025.100625

Deepu Habbanakuppe Ramakrishnegowda , Sweekar Baradekoppa Ramesh , Kampalapura S. Chandrakantha , Shobith Rangappa , Kanchugarakoppal S. Rangappa , Maralinganadoddi P. Sadashiva

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Abstract

Silver and nickel composites are known for enhancing biocatalytic activity and have substantial potential in biomedical engineering due to their comprehensive applications. Here, we synthesized an Ag₂O/NiO composite using the microwave hydrothermal method and characterized it by XRD, SEM, DLS, FTIR, TEM, and XPS analysis. The Ag₂O/NiO composite catalyst was tested against the breast cancer cell line MDA-MB-231 and showed dose-dependent growth inhibition with IC₅₀ values of 100, 250, 500, and 1000 μg/ml⁻¹ as determined by the MTT assay. In addition, the composite showed antimicrobial activity against Escherichia coli (MTCC 7410), Staphylococcus aureus (MTCC 7443), Fusarium oxysporum (RCMB 001004), and Aspergillus niger (RCMB 02724). These results suggest that the Ag₂O/NiO composite is an active biocatalyst with promising antimicrobial and anticancer properties.

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众所周知，银和镍复合材料可提高生物催化活性，由于其应用广泛，在生物医学工程中具有巨大潜力。在此，我们采用微波水热法合成了一种 Ag2O/NiO 复合材料，并通过 XRD、SEM、DLS、FTIR、TEM 和 XPS 分析对其进行了表征。Ag2O/NiO 复合催化剂针对乳腺癌细胞株 MDA-MB-231 进行了测试，结果表明其生长抑制作用呈剂量依赖性，经 MTT 试验测定，IC50 值分别为 100、250、500 和 1000 μg/ml-1。此外，该复合材料还对大肠杆菌（MTCC 7410）、金黄色葡萄球菌（MTCC 7443）、氧孢镰刀菌（RCMB 001004）和黑曲霉（RCMB 02724）具有抗菌活性。这些结果表明，Ag2O/NiO 复合材料是一种活性生物催化剂，具有良好的抗菌和抗癌特性。

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