Diabetic ketoacidosis treatment outcomes and associated factors among adult diabetic patients in Ethiopia: A systematic review and meta-analysis

Tsegaamlak Kumelachew Derse , Desalegn Metiku Kidie , Addisu Simachew Asgai , Tadios lidetu , Moges Tadesse Abebe
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Abstract

Background

Diabetic ketoacidosis is a severe complication of diabetes that can threaten life and has a considerable effect on healthcare systems, especially in developing nations such as Ethiopia. Although it is clinically significant, comprehensive data on the factors that lead to unsatisfactory treatment outcomes in diabetic ketoacidosis patients in Ethiopia are lacking. This review aims to investigate and evaluate unsatisfactory treatment outcomes and multiple contributing factors related to diabetic ketoacidosis among patients with diabetes in Ethiopia. This review seeks to identify these factors to provide insights that can guide improvements in the management and treatment of diabetic patients.

Methods

Articles documenting unfavorable treatment outcomes and related aspects of diabetic ketoacidosis among Ethiopian diabetes patients were meticulously sought from various databases, including PubMed/MEDLINE, the Cochrane Library, Science Direct, HINARI, Google Scholar, and gray literature. After the data were extracted, they were imported into Stata software version 17 for analysis. The Cochrane Q test and I2 statistic were used to evaluate heterogeneity.

Results

A total of 580 duplicates were eliminated from the initial set of 1578 papers obtained from PubMed (3), Google Scholar (1,550), HINARI (11), Science Direct (13), and the Cochrane Library (1). The pooled prevalence of poor treatment outcomes for diabetic ketoacidosis was 8 %. Key risk factors for poor treatment outcomes included a Glasgow Coma Scale (GCS) score of less than 15 (POR = 3.16; 95 % CI: 1.52–4.80), sepsis (POR = 2.92; 95 % CI: 1.12–4.72), and comorbidities (POR = 3.66; 95 % CI: 1.64–5.68).

Conclusion

The pooled prevalence of poor treatment outcomes of diabetic ketoacidosis in Ethiopia was high. A GCS score of less than 15, sepsis, and comorbidities were identified as significant risk factors for poor treatment outcomes in diabetic ketoacidosis patients. Addressing and minimizing these factors could help reduce the incidence of poor treatment outcomes in diabetic ketoacidosis patients in Ethiopia.
埃塞俄比亚成年糖尿病患者的糖尿病酮症酸中毒治疗结果和相关因素:系统回顾和荟萃分析
糖尿病酮症酸中毒是糖尿病的一种严重并发症,可威胁生命,对医疗保健系统有相当大的影响,特别是在埃塞俄比亚等发展中国家。虽然具有临床意义,但埃塞俄比亚缺乏导致糖尿病酮症酸中毒患者治疗结果不满意的因素的综合数据。本综述旨在调查和评价埃塞俄比亚糖尿病患者不满意的治疗结果和与糖尿病酮症酸中毒相关的多种因素。本综述旨在确定这些因素,为指导糖尿病患者管理和治疗的改进提供见解。方法从PubMed/MEDLINE、Cochrane图书馆、Science Direct、HINARI、谷歌Scholar和灰色文献等数据库中仔细检索记录埃塞俄比亚糖尿病患者不良治疗结果和糖尿病酮症酸中毒相关方面的文章。数据提取后,导入Stata软件版本17进行分析。采用Cochrane Q检验和I2统计量评价异质性。结果从PubMed(3)、谷歌Scholar(1550)、HINARI(11)、Science Direct(13)和Cochrane图书馆(1)获得的1578篇论文中,共剔除了580个重复。糖尿病酮症酸中毒治疗不良的总发生率为8%。不良治疗结果的关键危险因素包括格拉斯哥昏迷评分(GCS)低于15分(POR = 3.16;95% CI: 1.52-4.80),脓毒症(POR = 2.92;95% CI: 1.12-4.72),合并症(POR = 3.66;95% ci: 1.64-5.68)。结论埃塞俄比亚糖尿病酮症酸中毒治疗不良的总发生率较高。GCS评分小于15、脓毒症和合并症被认为是糖尿病酮症酸中毒患者治疗结果不佳的重要危险因素。解决和尽量减少这些因素可能有助于减少埃塞俄比亚糖尿病酮症酸中毒患者治疗结果不佳的发生率。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Metabolism open
Metabolism open Agricultural and Biological Sciences (General), Endocrinology, Endocrinology, Diabetes and Metabolism
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