The effect of intramyometrial injection of terlipressin versus carbetocin on hemoglobin and blood loss during open myomectomy operations without using haemostatic tourniquets: Double blinded randomized placebo-controlled trial

IF 2.1 4区医学 Q2 OBSTETRICS & GYNECOLOGY

European journal of obstetrics, gynecology, and reproductive biology Pub Date : 2025-03-22 DOI:10.1016/j.ejogrb.2025.03.041

Wael Elbanna , Mohammed Mahmoud Al Sheikh , Osama Mahmoud Azmy

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引用次数: 0

Abstract

Background

Uterine fibroids are a significant worldwide health problem due to their high prevalence among women during the reproductive period. Conservative surgery such as myomectomy has been of increasing interest. However, intraoperative blood loss represents a challenge to the surgeons. Therefore, the aim of this study was to assess the efficacy of Intramyometrial injection of terlipressin and carbetocin in reducing intraoperative bleeding and preserving the hemoglobin level.

Methods

We conducted the randomized, double-blind, placebo-controlled trial from February 2022 to April 2024, in the El-Resala and Al-Aseema hospitals under the direction of the National Research Center.

Results

A total of 99 eligible female patients out of 119 (13werenotmeetingtheinclusioncriteria) with uterine fibroid were recruited into the study and allocated into three groups (n = 33): terlipressin group (A), carbetocin group (B), and saline group (C). Blood loss was significantly different among groups (P < 0.001), being significantly lower in the Terlipressin group than the carbetocin group (mean = 321 vs 418 ml) and significantly lower in both groups than the saline (mean = 969 ml). The Terlipressin group required significantly less blood transfusion than the saline group (P < 0.05). The operative time and side effects were not statistically different among the three groups (P < 0.05).

The operative time and side effects were not statistically different among the three groups.

Conclusions

Our study provided evidence that terlipressin is effective in reducing blood loss during myomectomy with advantages over carbetocin. Based on our results, we recommend the adoption of terlipressin to improve myomectomy outcomes and enhance patient safety, further studies with a larger sample size is recommended to confirm our findings.

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来源期刊

European journal of obstetrics, gynecology, and reproductive biology 医学-妇产科学

CiteScore

4.60

自引率

3.80%

发文量

898

审稿时长

8.3 weeks

期刊介绍： The European Journal of Obstetrics & Gynecology and Reproductive Biology is the leading general clinical journal covering the continent. It publishes peer reviewed original research articles, as well as a wide range of news, book reviews, biographical, historical and educational articles and a lively correspondence section. Fields covered include obstetrics, prenatal diagnosis, maternal-fetal medicine, perinatology, general gynecology, gynecologic oncology, uro-gynecology, reproductive medicine, infertility, reproductive endocrinology, sexual medicine and reproductive ethics. The European Journal of Obstetrics & Gynecology and Reproductive Biology provides a forum for scientific and clinical professional communication in obstetrics and gynecology throughout Europe and the world.