Hui Li , Kaining Yang , Yumin Yang , Liqin Ding , Xiaoxia Li
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引用次数: 0
Abstract
Deep eutectic solvents (DESs) are a class of low-melting mixtures formed by the hydrogen-bond interactions between hydrogen bond acceptors (HBAs) and hydrogen bond donors (HBDs) in specific molar ratios. Their unique physicochemical properties enable DESs to significantly enhance drug solubility and permeability, while also serving as carriers to facilitate efficient drug delivery. A subclass of DESs, natural deep eutectic solvents (NADESs), is found in the metabolites of natural organisms, such as plants. With low toxicity and biodegradability, NADESs possess distinct advantages for applications in the pharmaceutical field.The therapeutic efficacy of drugs is often limited by imprecise release mechanisms, leading to the metabolism or degradation of a portion of the drug before it reaches the target site, thereby reducing its effectiveness. Moreover, many drugs exhibit poor solubility and stability, resulting in low efficiency during absorption and metabolism, which further diminishing their therapeutic impact. NADESs, with their excellent tunability and biocompatibility, have demonstrated great potential in drug delivery systems.This paper first provides an overview of the fundamental characteristics of NADESs, followed by a detailed summary of recent advancements and applications of NADESs across various administration routes, including transdermal, mucosal, and inhalation drug delivery. Finally, the paper explores the prospects of NADESs in novel drug delivery systems and proposes strategies for optimizing their performance to promote clinical applications.
期刊介绍:
The International Journal of Pharmaceutics is the third most cited journal in the "Pharmacy & Pharmacology" category out of 366 journals, being the true home for pharmaceutical scientists concerned with the physical, chemical and biological properties of devices and delivery systems for drugs, vaccines and biologicals, including their design, manufacture and evaluation. This includes evaluation of the properties of drugs, excipients such as surfactants and polymers and novel materials. The journal has special sections on pharmaceutical nanotechnology and personalized medicines, and publishes research papers, reviews, commentaries and letters to the editor as well as special issues.