Tuning the properties of multicomponent microspheres for synergistic bone regeneration

IF 6.5 2区材料科学 Q1 MATERIALS SCIENCE, COMPOSITES

Composites Communications Pub Date : 2025-03-19 DOI:10.1016/j.coco.2025.102348

Qingming Ji , Xia Sheng , Zhenyu Wang , Archana Bhaw-Luximon , Zongliang Wang , Min Guo , Yu Wang , Yi Liu , Peibiao Zhang

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引用次数: 0

Abstract

A bone graft with tunable chemical composition and biodegradability has been developed to enhance bone fusion and regeneration. This graft consists of calcium sulfate/polyetheretherketone (CaSO₄/PEEK) microspheres and hydroxyapatite/poly (lactic-glycolic acid) (HA/PLGA) microspheres. As the CaSO₄ content in the CaSO₄/PEEK microspheres increased from 10 % to 40 %, both the calcium content and the microstructural topology of the microspheres significantly improved, thereby enhancing in vitro mineralization and cellular response. Microspheres of varying ratios of CaSO₄/PEEK and HA/PLGA were implanted into critical-sized rat calvarial defects. Well-developed new bone tissue extended along the surface of the microspheres and grew into the space created by the degradation of the HA/PLGA microspheres. The bone defect region implanted with a mixture of CaSO₄/PEEK and HA/PLGA microspheres in a ratio of 5:5 or 7:3 fused with the edge of the host bone after 8 weeks. The structural support provided by the non-degradable CaSO₄/PEEK microspheres, combined with the new bone ingrowth facilitated by the degradable HA/PLGA microspheres, synergistically promoted the process of bone remodeling. Therefore, these multicomponent microspheres demonstrate significant potential in orthopedic bone grafting due to their ability to reduce the area of bone defects, shorten the distance for bone fusion, and accelerate bone healing.

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一种化学成分和生物降解性均可调的骨移植物已被开发出来，用于增强骨融合和骨再生。这种移植材料由硫酸钙/聚醚醚酮（CaSO4/PEEK）微球和羟基磷灰石/聚（乳酸-乙醇酸）（HA/PLGA）微球组成。随着 CaSO4/PEEK 微球中的 CaSO4 含量从 10% 增加到 40%，微球的钙含量和微结构拓扑都得到了显著改善，从而增强了体外矿化和细胞反应。将不同比例的 CaSO4/PEEK 和 HA/PLGA 微球植入临界大小的大鼠腓骨缺损处。发育良好的新骨组织沿着微球表面延伸，并在 HA/PLGA 微球降解后形成的空间中生长。植入 CaSO4/PEEK 和 HA/PLGA 微球混合物（比例为 5:5 或 7:3）的骨缺损区域在 8 周后与宿主骨边缘融合。不可降解的 CaSO4/PEEK 微球提供的结构支撑与可降解的 HA/PLGA 微球促进的新骨生长相结合，协同促进了骨重塑过程。因此，这些多组分微球具有减少骨缺损面积、缩短骨融合距离和加速骨愈合的能力，在骨科植骨方面具有巨大潜力。

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来源期刊

Composites Communications Materials Science-Ceramics and Composites

CiteScore

12.10

自引率

10.00%

发文量

340

审稿时长

36 days

期刊介绍： Composites Communications (Compos. Commun.) is a peer-reviewed journal publishing short communications and letters on the latest advances in composites science and technology. With a rapid review and publication process, its goal is to disseminate new knowledge promptly within the composites community. The journal welcomes manuscripts presenting creative concepts and new findings in design, state-of-the-art approaches in processing, synthesis, characterization, and mechanics modeling. In addition to traditional fiber-/particulate-reinforced engineering composites, it encourages submissions on composites with exceptional physical, mechanical, and fracture properties, as well as those with unique functions and significant application potential. This includes biomimetic and bio-inspired composites for biomedical applications, functional nano-composites for thermal management and energy applications, and composites designed for extreme service environments.