Functional connectivity of the default mode network subsystems alterations in suicide attempters with major depressive disorder

IF 3.8 4区医学 Q1 PSYCHIATRY

Asian journal of psychiatry Pub Date : 2025-03-23 DOI:10.1016/j.ajp.2025.104456

Yigao Wu , Wenhao Jiang , Man Chen , Qin Jiang , Huilan Huang , Wenbin Guo , Yonggui Yuan

{"title":"Functional connectivity of the default mode network subsystems alterations in suicide attempters with major depressive disorder","authors":"Yigao Wu , Wenhao Jiang , Man Chen , Qin Jiang , Huilan Huang , Wenbin Guo , Yonggui Yuan","doi":"10.1016/j.ajp.2025.104456","DOIUrl":null,"url":null,"abstract":"<div><div>Default mode network (DMN) abnormalities are common in patients with major depressive disorder and suicide attempts (MDD-SA). We aimed to investigate the abnormal functional connectivity (FC) patterns of DMN in MDD-SA. Seventeen DMN components were extracted from 55 MDD-SA, 94 patients with MDD but without suicide attempts (MDD-NoSA), and 71 healthy controls (HC). Compared with HC and MDD-NoSA, patients with MDD-SA revealed reduced FC between the dorsomedial prefrontal cortex (dMPFC) seed and middle frontal gyrus (MFG). Patients with MDD-SA also showed specific increased FC between ventral medial prefrontal cortex (vMPFC) seed and medial superior frontal gyrus. MDD-NoSA showed specific increased FC between dMPFC and cerebellum crus Ⅱ. Both patients with MDD-SA and MDD-NoSA demonstrated increased FC between the vMPFC seed and inferior parietal lobule (IPL) and impaired FC between the anterior medial prefrontal cortex and cerebellum crus Ⅱ than HC. Furthermore, the abnormal FC between the vMPFC seed and IPL was correlated with Montgomery-Asberg Depression Scale in the MDD-NoSA group. Our findings highlighted that these abnormal FC patterns of DMN were associated with pathological mechanisms in patients with MDD-SA and MDD-NoSA.</div></div>","PeriodicalId":8543,"journal":{"name":"Asian journal of psychiatry","volume":"107 ","pages":"Article 104456"},"PeriodicalIF":3.8000,"publicationDate":"2025-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Asian journal of psychiatry","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1876201825000991","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PSYCHIATRY","Score":null,"Total":0}

引用次数: 0

Abstract

Default mode network (DMN) abnormalities are common in patients with major depressive disorder and suicide attempts (MDD-SA). We aimed to investigate the abnormal functional connectivity (FC) patterns of DMN in MDD-SA. Seventeen DMN components were extracted from 55 MDD-SA, 94 patients with MDD but without suicide attempts (MDD-NoSA), and 71 healthy controls (HC). Compared with HC and MDD-NoSA, patients with MDD-SA revealed reduced FC between the dorsomedial prefrontal cortex (dMPFC) seed and middle frontal gyrus (MFG). Patients with MDD-SA also showed specific increased FC between ventral medial prefrontal cortex (vMPFC) seed and medial superior frontal gyrus. MDD-NoSA showed specific increased FC between dMPFC and cerebellum crus Ⅱ. Both patients with MDD-SA and MDD-NoSA demonstrated increased FC between the vMPFC seed and inferior parietal lobule (IPL) and impaired FC between the anterior medial prefrontal cortex and cerebellum crus Ⅱ than HC. Furthermore, the abnormal FC between the vMPFC seed and IPL was correlated with Montgomery-Asberg Depression Scale in the MDD-NoSA group. Our findings highlighted that these abnormal FC patterns of DMN were associated with pathological mechanisms in patients with MDD-SA and MDD-NoSA.

查看原文本刊更多论文

求助全文

约1分钟内获得全文求助全文

来源期刊

Asian journal of psychiatry Medicine-Psychiatry and Mental Health

CiteScore

12.70

自引率

5.30%

发文量

297

审稿时长

35 days

期刊介绍： The Asian Journal of Psychiatry serves as a comprehensive resource for psychiatrists, mental health clinicians, neurologists, physicians, mental health students, and policymakers. Its goal is to facilitate the exchange of research findings and clinical practices between Asia and the global community. The journal focuses on psychiatric research relevant to Asia, covering preclinical, clinical, service system, and policy development topics. It also highlights the socio-cultural diversity of the region in relation to mental health.