Trends and spatial distribution of the burden of vaccine-preventable diseases in children under five in Brazil from 2000 to 2019

IF 4.5 3区医学 Q2 IMMUNOLOGY

Vaccine Pub Date : 2025-03-30 DOI:10.1016/j.vaccine.2025.127060

Tércia Moreira Ribeiro da Silva , Ana Carolina Micheletti Gomide Nogueira de Sá , Elton Junio Sady Prates , Guilherme Augusto Veloso , Bárbara Aguiar Carrato , Crizian Saar Gomes , Monsen Naghavi , Deborah Carvalho Malta

{"title":"Trends and spatial distribution of the burden of vaccine-preventable diseases in children under five in Brazil from 2000 to 2019","authors":"Tércia Moreira Ribeiro da Silva , Ana Carolina Micheletti Gomide Nogueira de Sá , Elton Junio Sady Prates , Guilherme Augusto Veloso , Bárbara Aguiar Carrato , Crizian Saar Gomes , Monsen Naghavi , Deborah Carvalho Malta","doi":"10.1016/j.vaccine.2025.127060","DOIUrl":null,"url":null,"abstract":"<div><h3>Objective</h3><div>To analyze mortality burden and spatial distribution of vaccine-preventable diseases in children under five in Brazil from 2000 to 2019.</div></div><div><h3>Study design</h3><div>Ecological study.</div></div><div><h3>Methods</h3><div>Study using vaccination coverage data from 2000 to 2019 across 5570 Brazilian municipalities, and mortality estimates from the Global Burden of Disease 2019. Spatial analyses were conducted to identify statistically significant clusters (<em>p</em> < 0.05) and spatial autocorrelation.</div></div><div><h3>Results</h3><div>There was a reduction in mortality from vaccine-preventable diseases in Brazil between 2000 and 2019. The North and Northeast regions showed high mortality rates and lower vaccination coverage compared to other regions.</div></div><div><h3>Conclusions</h3><div>Infant mortality in Brazil decreased significantly, especially after improvements in vaccination coverage. However, this reduction was not uniform, with the North and Northeast regions showing clusters of high mortality.</div></div>","PeriodicalId":23491,"journal":{"name":"Vaccine","volume":"55 ","pages":"Article 127060"},"PeriodicalIF":4.5000,"publicationDate":"2025-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Vaccine","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0264410X25003573","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"IMMUNOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Objective

To analyze mortality burden and spatial distribution of vaccine-preventable diseases in children under five in Brazil from 2000 to 2019.

Study design

Ecological study.

Methods

Study using vaccination coverage data from 2000 to 2019 across 5570 Brazilian municipalities, and mortality estimates from the Global Burden of Disease 2019. Spatial analyses were conducted to identify statistically significant clusters (p < 0.05) and spatial autocorrelation.

Results

There was a reduction in mortality from vaccine-preventable diseases in Brazil between 2000 and 2019. The North and Northeast regions showed high mortality rates and lower vaccination coverage compared to other regions.

Conclusions

Infant mortality in Brazil decreased significantly, especially after improvements in vaccination coverage. However, this reduction was not uniform, with the North and Northeast regions showing clusters of high mortality.

查看原文本刊更多论文

求助全文

约1分钟内获得全文求助全文

来源期刊

Vaccine 医学-免疫学

CiteScore

8.70

自引率

5.50%

发文量

992

审稿时长

131 days

期刊介绍： Vaccine is unique in publishing the highest quality science across all disciplines relevant to the field of vaccinology - all original article submissions across basic and clinical research, vaccine manufacturing, history, public policy, behavioral science and ethics, social sciences, safety, and many other related areas are welcomed. The submission categories as given in the Guide for Authors indicate where we receive the most papers. Papers outside these major areas are also welcome and authors are encouraged to contact us with specific questions.