New estimation of electron and photon internal dose coefficients for new adult female computational phantom using DoseCalcs

IF 2.8 3区 物理与天体物理 Q3 CHEMISTRY, PHYSICAL
Tarik El Ghalbzouri , Tarek El Bardouni , Jaafar El Bakkali , Mohamed Drissi El-Bouzaidi , Hicham Satti
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引用次数: 0

Abstract

Internal radiation dosimetry is critical in nuclear medicine procedures involving radiopharmaceuticals as it evaluates the risks and benefits of diagnostic and therapeutic applications. In this context, radiological protection quantities, including absorbed dose and effective dose, are derived from the specific absorbed fraction (SAF), a fundamental dose coefficient. The SAF quantifies the fraction of energy deposited in a target region per unit mass relative to the energy emitted from a specified source region.
Updating the SAF dataset using the latest mesh-type computational phantoms is strongly recommended. Comparing these values with SAFs from earlier voxel-based phantoms helps identify targetsource combinations with variations in internal dosimetry coefficients, reflecting the anatomical improvements in mesh-type phantoms.
Simulations using the DoseCalcs platform were conducted for electron and photon transport at eight energies (10 keV to 2 MeV), employing the adult female mesh-type phantom from ICRP Publication 145. Subsequently, SAFs were calculated for twenty-four distinct source regions and compared with those derived by OpenDose using the voxel-based model.
The results showed that SAFs calculated with mesh-type and voxel-based phantoms are similar, with minor differences observed for both photons and electrons. Notable variations were observed for photons in the spleenliver combination and for electrons at low energy, particularly in the pancreasliver and liverpancreas combinations. These differences highlight the impact of anatomical improvements in mesh-type phantoms. These differences arise from improved internal structures, particularly for adjacent organs/tissues, due to differences in contact surface geometry. The mesh-type model uses smooth surfaces, while the voxel-based model employs stair-based surfaces.
内部辐射剂量测定在涉及放射性药物的核医学程序中至关重要,因为它可以评估诊断和治疗应用的风险和效益。在这种情况下,包括吸收剂量和有效剂量在内的辐射防护量都来自于基本剂量系数--比吸收分量(SAF)。比吸收分数量化了相对于特定源区发射的能量而言,单位质量沉积在靶区的能量分数。将这些值与早期基于体素的模型的SAF值进行比较,有助于确定内部剂量测定系数有变化的目标←源组合,反映出网状模型在解剖学上的改进。利用DoseCalcs平台进行了八种能量(10 keV至2 MeV)的电子和光子传输模拟,并采用了ICRP第145号出版物中的成年女性网状模型。结果表明,使用网状模型和基于体素的模型计算出的 SAFs 相似,光子和电子的 SAFs 稍有不同。在脾脏←肝脏组合中的光子和低能量电子中观察到明显的差异,特别是在胰腺←肝脏和肝脏←胰腺组合中。这些差异凸显了解剖学改进对网状模型的影响。这些差异源于内部结构的改进,特别是相邻器官/组织的内部结构,这是由于接触面几何形状的不同造成的。网格模型使用光滑表面,而基于体素的模型使用阶梯表面。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Radiation Physics and Chemistry
Radiation Physics and Chemistry 化学-核科学技术
CiteScore
5.60
自引率
17.20%
发文量
574
审稿时长
12 weeks
期刊介绍: Radiation Physics and Chemistry is a multidisciplinary journal that provides a medium for publication of substantial and original papers, reviews, and short communications which focus on research and developments involving ionizing radiation in radiation physics, radiation chemistry and radiation processing. The journal aims to publish papers with significance to an international audience, containing substantial novelty and scientific impact. The Editors reserve the rights to reject, with or without external review, papers that do not meet these criteria. This could include papers that are very similar to previous publications, only with changed target substrates, employed materials, analyzed sites and experimental methods, report results without presenting new insights and/or hypothesis testing, or do not focus on the radiation effects.
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