Surface-enhanced Raman spectroscopy facilitates the detection of multiple metabolic modulators

IF 4.3 2区化学 Q1 SPECTROSCOPY

Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy Pub Date : 2025-03-26 DOI:10.1016/j.saa.2025.126121

Yueyue Ma , Na Zhou , Zhichao Xia , Yushi Shen , Tao Yang , Xiaojun Luo , Yuanyuan Li

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引用次数: 0

Abstract

Metabolic regulators can improve the athletic ability of athletes by regulating body metabolism, but it is not conducive to fair competition, so it is listed as a prohibited substance. At the same time, the State General Administration of Sport ordered major event organizers to test food for food-borne stimulants. Surface-enhanced Raman scattering (SERS) spectroscopy has been widely used because of its excellent sensitivity and strong spectral characteristics. Based on the available information, SERS spectrum data of metabolic regulators in food-related fields were lacking. In this study, we used gold dodecahedron nanoparticles as SERS active substrate and successfully captured the characteristic peaks of 6 metabolic regulatory factors. A low cost and stable SERS detection technique for detecting trimetazidine in milk samples with good recovery rate was proposed. Therefore, this method can not only protect the food safety of large-scale sports events, but also have broad application prospects in the food field.

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代谢调节剂可以通过调节人体新陈代谢提高运动员的运动能力，但不利于公平竞赛，因此被列为禁用物质。与此同时，国家体育总局下令各大赛事主办方对食品中的食源性兴奋剂进行检测。表面增强拉曼散射（SERS）光谱技术因其卓越的灵敏度和强大的光谱特性而得到广泛应用。根据现有资料，在食品相关领域缺乏代谢调节剂的 SERS 光谱数据。本研究采用十二面体金纳米粒子作为 SERS 活性底物，成功捕获了 6 种代谢调节因子的特征峰。该研究提出了一种低成本、稳定且回收率高的 SERS 检测技术，用于检测牛奶样品中的曲美他嗪。因此，该方法不仅可以保障大型体育赛事的食品安全，在食品领域也有广阔的应用前景。

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来源期刊

Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 物理-光谱学

CiteScore

8.40

自引率

11.40%

发文量

1364

审稿时长

40 days

期刊介绍： Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy (SAA) is an interdisciplinary journal which spans from basic to applied aspects of optical spectroscopy in chemistry, medicine, biology, and materials science. The journal publishes original scientific papers that feature high-quality spectroscopic data and analysis. From the broad range of optical spectroscopies, the emphasis is on electronic, vibrational or rotational spectra of molecules, rather than on spectroscopy based on magnetic moments. Criteria for publication in SAA are novelty, uniqueness, and outstanding quality. Routine applications of spectroscopic techniques and computational methods are not appropriate. Topics of particular interest of Spectrochimica Acta Part A include, but are not limited to: Spectroscopy and dynamics of bioanalytical, biomedical, environmental, and atmospheric sciences, Novel experimental techniques or instrumentation for molecular spectroscopy, Novel theoretical and computational methods, Novel applications in photochemistry and photobiology, Novel interpretational approaches as well as advances in data analysis based on electronic or vibrational spectroscopy.